Analysis of liver function indexes in 78 cases of early pregnancy patients with vomiting
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摘要: [目的]探讨孕早期妊娠呕吐妇女肝功能指标变化及临床意义，为孕妇产前保健与及时发现妊娠期肝脏疾病提供依据。[方法]选取2014年3月~2015年2月至我院就诊的78例孕早期妊娠剧吐患者，依据肝功能分为孕早期妊娠剧吐肝功能正常组（B组）43例和孕早期妊娠剧吐肝功能异常组（C组）35例，另外选取同期正常孕早期妊娠妇女40例为A组，40例健康非妊娠妇女为对照组；采用自动生化分析仪测定肝功能相关指标；单因素方差分析与LSD检验比较各组指标之间差异。[结果]血清ALT、AST、5'NT、GGT水平C组明显高于对照组、A组、B组（P<0.05），对照组、A组、B组之间比较差异无统计学意义，A组AST水平低于对照组，差异无统计学意义；B组ALP水平明显低于对照组、A组（P<0.05），其余各组之间差异无统计学意义；LDH水平在4组之间比较差异无统计学意义；血清TBIL、DBIL、IBIL、TBA水平C组明显高于对照组、A组、B组（P<0.05），对照组、A组、B组之间比较差异无统计学意义；C组TP、ALB、GLB水平明显低于对照组与A组（P<0.05），与B组比较差异无统计学意义，A/G水平C组明显低于对照组（P<0.05）。[结论]孕早期妊娠剧吐患者肝功能指标存在异常，监测肝功指标有助于及时发现妊娠期肝脏疾病。Abstract: [Objective] To explore the clinical significance of liver function indexes in early pregnancy patients with vomiting in order to provide evidence of prenatal care for pregnant women and to detect liver disease in pregnancy women.[Methods] A total of 78 cases of early pregnancy patients with vomiting from March 2014 to February 2015 in our hospital were selected and divided into normal liver function group(group B) 43 cases and abnormal liver function(group C) 35 cases.Another 40 cases of normal trimester pregnant women were chosen in the same period as group A.Forty healthy non-pregnant women were selected as the control group.The relevant indicators of liver function were detected by automatic biochemical analyzer.The data were analyzed by single ANOVA and LSD test.[Results] Serum ALT, AST, 5'NT, GGT levels in group C were significantly higher than that in the rest three groups(P<0.05).There was no significant differences between the control group, group A, and group B.The AST levels in group A was lower than that in the control group, with no significant difference.ALP levels in group B were significantly lower than the control group and group A(P<0.05).There was no significant difference between the other groups.LDH levels in four groups had no significant difference.Serum TBIL, DBIL, IBIL, and TBA levels in group C were significantly higher than that in the control group, group A, and group B(P<0.05).There was no significant difference between the control group, group A, and group B.TP, ALB, and GLB levels in group C were significantly lower than the control group and group A(P<0.05), no statistically significant difference between group B.A/G level in group C was significantly lower than in the control group(P<0.05).[Conclusion] The results show that the liver function indexes in early pregnancy patients with hyperemesis gravidarum are abnormal;monitoring liver function helps to detect liver disease during pregnancy.
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Key words:
- early pregnancy /
- liver function /
- bilirubin /
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