Association between nonalcoholic fatty liver disease and coronary heart disease and characteristics of coronary artery atherosclerosis
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摘要: [目的]探讨非酒精性脂肪肝病（NAFLD）与冠状动脉动脉粥样硬化病变的关系。[方法]84例疑诊冠心病患者同时检测血生化指标、肝脏超声和行冠脉CTA检查，并将患者分为NAFLD组（97例）和非NAFLD组（87例），比较2组一般情况、冠心病患病率、冠脉病变特点，采用二分类Logistic回归分析冠心病的危险因素。[结果]NAFLD组体质指数、吸烟率、糖尿病和高血压病患病率、TC、TG、ALT水平均明显高于非NAFLD组（P<0.05）。NAFLD组冠心病患病率、多支病变率及非钙化斑块率均高于非NAFLD组（P<0.05）。多因素Logistic回归分析显示NAFLD增加冠心病发病风险[P=0.013，OR=4.116，95%CI（1.904~9.270）]。[结论]NAFLD是冠心病独立危险因素，且与冠脉病变严重程度相关。Abstract: [Objective] To explore the association between nonalcoholic fatty liver disease(NAFLD) and coronary heart disease(CHD).[Methods] Clinical data including blood biochemical index, liver ultrasound and coronary CTA of 184 patients with suspected CHD were collected and divided into NAFLD group(97 cases) and non NAFLD group(87 cases).The general situation, morbidity rate of CHD and characteristics of coronary artery atherosclerosis were compared.A logistic regression analysis was performed to evaluate the risk factors of CHD.[Results] The body mass index, smoking rate, morbidity rate of diabetes and hypertension, and the levels of TC, TG, and ALT of NAFLD group were significantly higher than those in non NAFLD group(P<0.05).Multivariate Logistic regression analysis showed that NAFLD increased the risk of CHD[P=0.013, OR=4.116, 95%CI(1.904~9.270)].[Conclusion] NAFLD is an independent predicator for CHD and is related to the severity of CHD.
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