Relationship between serum gastrin level and stress ulcer in severe burns patients
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摘要: [目的]探讨重度烧伤患者血清胃泌素（GAS）水平与应激性溃疡的关系。[方法]选取2011年6月~2014年10月来我院就诊的70例重度烧伤患者，分为非溃疡组（34例）和溃疡组（36例），所有患者均于伤后不同时间检测血清GAS表达水平以及APACHEⅡ评分，并比较不同烧伤面积患者之间血清GAS表达水平。[结果]溃疡组患者不同时间血清GAS水平均显著低于非溃疡组（P<0.01）；烧伤患者在2 h后胃泌素水平降低，2~12 h胃泌素水平持续处于降低状态，13~24 h出现高峰，24 h后降低，48 h后维持相对稳定水平；不同烧伤面积患者血清GAS水平比较，差异具有统计学意义（P<0.05）；不同程度APACHEⅡ评分患者血清GAS水平比较，差异具有统计学意义（P<0.05），且APACHEⅡ评分与GAS水平之间呈正相关（P<0.05）。[结论]重度烧伤患者应激性溃疡与血清胃泌素相关，GAS水平与患者烧伤程度存在一定关系，患者烧伤后随时间延长，血清GAS水平呈现一定规律性。Abstract: [Objective] To explore the relation between serum gastrin levels(GAS) and stress ulcer in severe burn patients.[Methods] A total of 70 cases of severe burn patients from June 2011 to October 2014 in our hospital were selected.They were divided into non-ulcer group(34 cases) and ulcer group(36 cases).The GAS level and APACHEⅡ scores were detected after injury at different time points.The GAS levels of patients with different burn area were compared and analyzed.[Results] The GAS levels of ulcer patients at different time points were significantly lower than the non-ulcer group(P<0.01). GAS level reduced after 2 h, and continued to decrease during 2 to 12 h. After 13 to 24 h, GAS level reached a peak and then decreased after 24 h, which remained relatively stable after 48 h.Comparison of GAS in different burn area and different APACHEⅡ scores, the difference was statistically significant(F=32.5661, P<0.05).There was a positive correlation between(P<0.05), APACHEⅡ score and GAS levels(r=0.796, P<0.05).[Conclusion] It shows that stress ulcers associate with serum gastrin in patients with severe burns. There is a certain relationship between GAS and burn degree, and serum GAS shows certain regularity with time extending.
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Key words:
- severe burns /
- gastrin /
- stress ulcer
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