Abstract: [Objective] To investigate the treatment of sodium deoxycholate bear bile reflux gastritis and clinical effects observed in patients with stomach bile 24 h influence the situation.[Methods] Screening March 2013 to March 2014 in our hospital diagnosed by clinical bile reflux gastritis 68 cases, as the research object.Using a random number table method to all patients was divided into observation group and control group, 34 cases in each group.The control group was treated with conventional therapy, namely joint Mosapride Hydrotalcite combination therapy;the observation group bears sodium deoxycholate treatment group took control based on statistical treatment of the two groups of patients with total efficiency and stomach 24 h bile affect the results and compare.[Results] The patients in the observation group were cured 15 cases, effective 17 cases, total effective rate was 94.12%.Compared with control group, there was a significant difference(P<0.05);patients in the observation group after 24 h reflux episodes, reflux times longer than 5 min, the longest reflux time, total time and there were significant differences between pre-treatment comparison, and significantly higher than the control group has the advantage, P<0.05, statistically significant.[Conclusion] Combination therapy sodium deoxycholate bear bile reflux gastritis clinical results significantly enhance the efficacy of the more traditional treatment programs, which can effectively relieve symptoms of reflux gastritis and reduce the number of reflux time.