肝康Ⅱ号联合乳果糖保留灌肠治疗乙肝相关性肝衰竭肠源性内毒素血症

占国清; 谭华炳; 刘翔; 李儒贵

doi:10.3969/j.issn.1671-038X.2015.04.13

肝康Ⅱ号联合乳果糖保留灌肠治疗乙肝相关性肝衰竭肠源性内毒素血症

- 湖北医药学院附属人民医院感染性疾病科, 湖北十堰 442000

详细信息

作者简介:
占国清,主任医师,研究方向:感染性疾病临床科研工作

通讯作者: 占国清,E-mail:syrmhospital@aliyun.com

中图分类号: R575.1

收稿日期: 2014-11-26

The effect observation of GankangⅡ combined with lactulose in treating intestinal endotoxemia in patients with HBV-related liver failure

- Department of Infectious Disease, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China

More Information

Corresponding author: ZHAN Guo-qing, E-mail: syrmhospital@aliyun.com

Received Date: 26 November 2014

摘要

摘要: [目的]观察肝康Ⅱ号联合乳果糖保留灌肠治疗乙肝相关性肝衰竭肠源性内毒素血症（IETM）的疗效。[方法]将72例乙肝相关性肝衰竭患者随机分为观察组（40例）和对照组（32例）。2组均给予内科综合治疗，观察组在此基础上加用中药汤剂肝康Ⅱ号和乳果糖保留灌肠，1次/d，共3周，比较2组治疗后血清总胆红素（TBil）、白蛋白（ALB）、凝血酶原活动度（PTA）、内毒素（ET）水平、并发症及治疗3个月后病死率。[结果]治疗后与对照组比较，观察组血清TBil、ET明显降低，PTA明显升高（P<0.05或P<0.01）；观察组有效率（72.5%）高于对照组（46.9%）（P<0.05）；其肝性脑病（HE）、自发性细菌性腹膜炎（SBP）发生率分别为10.0%和25.0%，低于对照组40.6%和59.4%（P<0.01），但2组其他并发症和病死率比较，差异无统计学意义。[结论]肝康Ⅱ号联合乳果糖保留灌肠治疗乙肝相关性肝衰竭，可降低患者血清ET水平，改善肝功能和凝血功能，降低并发症发生率和病死率，疗效显著。
- 肝炎病毒,乙型 /
- 肝功能衰竭 /
- 肝康Ⅱ号 /
- 乳果糖 /
- 内毒素血症
Abstract: [Objective] To observe the clinical efficacy of Gankang Ⅱ combined with lactulose in treating intestinal endotoxemia(IETM) in patients with HBV-related liver failure.[Methods] Seventy-two patients with HBV-related liver failure were randomly divided into observation group(40 cases) and control group(32 cases).The two groups received conventional treatment, the observation group were given Gankang Ⅱ and lactulose decoction enema on the basis of conventional treatment, one daily for three weeks.After treatment, the levels of serum TBil, ALB, prothrombin active(PTA) and endotoxin(ET), complications and fatality rates after 3 menths of the two groups were compared respectively.[Results] Compared with the control group, the serum TBil, ET in observation group reduced obviously, PTA elevated obviously(P<0.05 orP<0.01).Efficiency of observation group was 72.5%, which was significantly higher than 46.9% of control group(P<0.05).The incidence rates of hepatic encephalopathy(HE) and spontaneous bacterial peritonitis(SBP) in observation group were 10.0% and 25.0%, which were lower than those in control group(40.6% and 59.4%) (P<0.01).There were no significant difference in other complications and the mortality rate between the two groups.[Conclusion] Gankang Ⅱ combined with lactulose can decrease seram endotoxin level, improve liver function and coagulation function, and reduce complications and fatality rate in the treatment of HBV-related liver failure.
- Hepatitis B virus /
- liver failure /
- Gankang Ⅱ /
- lactulose /
- endotoxin

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