Clinical study on Fuzheng Quxie Formula combined with western medicine in eradicating Helicobacter pylori
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摘要: [目的]观察以扶正祛邪为主的中药联合抗幽门螺杆菌(Hp)四联根除方案治疗Hp的根除率、症状改善及不良反应发生情况。[方法]以2011年1月~2012年12月在我院治疗的门诊或住院Hp感染患者60例,随机分为观察组和对照组。观察组接受扶正祛邪的中药方剂+四联根除方案,对照组接受单纯四联根除方案,疗程均为7d。比较2两组患者Hp根除率、主要症状改善及不良反应发生率等。[结果]2组患者用药后症状均有好转,观察组患者的上腹痛及反酸改善明显优于对照组(P<0.05);Hp根除率(93.33%)明显高于对照组(73.33%)(P<0.05)。观察组有4例患者发生不良反应,对照组有5例发生不良反应,均未影响后续治疗。[结论]以扶正祛邪为主的中医药联合四联根除方案治疗Hp感染具有明显的优势,可明显提高Hp根除率,明显改善患者的上腹痛和反酸等症状,不良反应小。Abstract: [Objective] To observe the efficacy and side effect of traditional Chinese medicine combined with western medicine on eradication of Helicobacter pylori (Hp).[Methods] Sixty Hp-infected patients in our hospital were randomly divided into the observation group and the control group.Patients in the observation group received Chinese prescription plus quadruple therapy of western medicine. Meanwhile, patients in the control group only received western medicine.The Hp eradication rates, symptoms and adverse events were recorded.[Results] After treatment,patients’ symptoms were improved in both groups. The upper abdominal pain and acid reflux in observation group improved significantly compared to control group (P<0.05);Hp eradication rate (93.33%) of the observation group was significantly higher than that of the control group (73.33%) (P<0.05).Four cases showed adverse reactions in observation group, while 5 cases showed adverse reactions in control group. The subsequent treatment was not interrupted. [Conclusion] The traditional Chinese medicine combined with western medicine can significantly improve the H.pylori eradication rate, patient's upper abdominal pain and acid reflux symptoms.At the same time,the treatment is safe.
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Key words:
- Fuzheng Quxie /
- quadruple eradication programs /
- Helicobacter pylori
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[1] 陆菁菁.简述Hp相关性胃炎治疗中有关根除Hp的中西药治疗近况[J].中医临床研究,2012,4(6):11-12.
[2] 李晓宁,胡伏莲.幽门螺杆感染治疗的研究进展[J].中国新药杂志,2002,11(1):1174-1177.
[3] 黄文凤,陈国辉.中药抗幽门螺杆菌概述[J].海峡药学,2009,21(3):82-83.
[4] 程多慧,沈洪.根除幽门螺杆菌的中医药研究及临床应用概况[J].中国民族民间医药杂志,2011,20(1):16-17.
[5] 郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:l34-l35.
[6] 中华医学会消化病学分会.幽门螺杆菌若干问题的共识意见[C].中华消化杂志,2000,20(2):117-118.
[7] 平泽康史,杜旭.黄连解毒汤对幽门螺杆菌的抗菌作用[J].国外医学:中医中药分册,2003,25(2):97-98.
[8] 高改琴,刘晓琳.幽门螺杆菌感染与慢性胃炎伴肠上皮化生和/或伴非典型增生的相关性探讨[J].中国内镜杂志,2007,13(5):533-534.
[9] 周晶,汪红兵,陈飞松,等.中医药治疗幽门螺杆菌相关性胃病的研究进展[J].中国中西医结合消化杂志,2001,9(5):316-318.
[10] 李静芸.慢性胃炎中医证型与幽门螺杆菌的相关性研究进展[J].实用中医内科杂志,2006,20(6):579-580.
[11] 刘旸,潘健.黄芪建中汤加减治疗幽门螺杆曲相关性胃炎疗效观察[J].中华今日医学杂志,2004,4(6):681-681.
[12] 陈岚,周镇苏,黄金华.中药清幽片治疗幽门螺旋杆菌胃病的临床体会[J].铁道医学,1997,25(6):56-56.
[13] 胡伏莲.《幽门螺杆菌感染若干问题共识意见》解读[J].中国医刊,2007,42(1):5-6.
[14] 丁衍文.朱建华教授中西结合治疗慢性胃炎经验[J].环球中医药,2009,2(5):347-348.
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