Abstract: [Objective] To explore the effects of Weiwei granule on NF-κB and endogenous IκBα expressions in gastric mucosa of chronic atrophic gastritis (CAG) rats and further investigate the mechanisms.[Methods] With the comprehensive methods,the rat models of CAG were established and assigned into normal group,modeling group and Weiwei granule groups with low,middle and high doses,and the effects of Weiwei granule on NF-κB and IκBα expressions in gastric mucosa of CAG rats were observed.[Results] The OD values of NF-κB protein were 0.116±0.033 in the normal group,0.183±0.035 in the modeling group,0.158±0.031 in the low-dose Weiwei granule group,0.144±0.039 in the middle-dose Weiwei granule group and 0.126±0.036 in the high-dose Weiwei granule group.Compared with that in the modeling group,the OD values in all the Weiwei granule groups were obviously decresed (P<0.01),which had the tendency of dosage-dependency,namely,low-dose group showed the highest NF-κB expression and high-dose group showed the lowest NF-κB expression,with significant difference among the three groups (P <0.01);The OD values of IκBα protein were 4.25±1.02 in the normal group,2.08±0.74 in the modeling group,2.77±0.78 in the low-dose Weiwei granule group,3.46±0.84 in the middle-dose Weiwei granule group and 4.12±0.96 in the high-dose Weiwei granule group.Compared with that in the modeling group,the OD values in all the Weiwei granule groups were apparently increased (P <0.01),which also had the tendency of dosage-dependency,with significant difference among the three groups (P<0.01).[Conclusion] Weiwei granule might up-regulate the IκBα expression in the gastric mucosa of CAG rats,promote the integration of IκBα and NF-κB and inhibit the activation of NF-κB,hence lowering the inflammation of gastric mucosa,effectively inhibiting the hyperplasia of gastric mucosa and preventing the CAG further transformation into gastric carcinoma.