康复新液联合胶体果胶铋或(和)奥美拉唑治疗胃溃疡有效性和安全性比较

于辉; 周连泉; 赵鹏

doi:10.3969/j.issn.1671-038X.2013.07.006

康复新液联合胶体果胶铋或(和)奥美拉唑治疗胃溃疡有效性和安全性比较

- 1 山东德州学院临床护理教研室, 山东德州 253023;
- 2 德州市人民医院消化内科, 山东德州 253014;
- 3 德州市人民医院内二科, 山东德州 253014

详细信息

作者简介:
于辉,男,医学硕士,主任医师,教授,从事临床护理教学,消化内科临床疾病诊断与治疗及生物活性递质在消化系统的分布及功能研究

中图分类号: R573.1

收稿日期: 2013-04-10

A randomized,controlled study in the treatment of gastrohelcoma using Kangfuxin liquid combined with colloidal bismuth PECT in-739 and/or omeprazole

- 1. Clinical Nursing Staff Room, Dezhou College, Dezhou 253023, China;
- 2. Department of Gastroenterology, the People's Hospital of Dezhou, Dezhou 253014, China;
- 3. the Second Section of Internal Medicine, the People's Hospital of Dezhou, Dezhou 253014, China

Received Date: 10 April 2013

摘要

摘要: [目的]比较康复新液联合胶体果胶铋或(和)奥美拉唑治疗胃溃疡(GU)有效性和安全性。[方法]278例GU患者连续随机地分为:康复新组(A组);康复新+胶体果胶铋组(B组);康复新+奥美拉唑组(C组);康复新+胶体果胶铋+奥美拉唑组(D组)。A组口服康复新治疗,B组在A组的基础上加服胶体果胶铋,C组在A组的基础上加服奥美拉唑;D组在B组的基础上加服奥美拉唑。治疗4周后观察4组患者的腹痛、上腹胀、恶心、呕吐、纳差嗳气、反酸、烧心(或胸骨后烧灼感)等情况及不良反应。[结果]A、B、C、D组治疗后恶心、呕吐改善总有效率分别为50.72%、72.22%、50.74%、75.71%,B、D组与A组,C组与D组比较均差异有统计学意义(P<0.05);A、B、C、D组治疗后腹痛、腹胀改善总有效率分别为52.17%、68.06%、65.67%、95.71%,A、B、C组与D组比较均差异有统计学意义(P<0.05),A组与B组、A组与C组比较差异无统计学意义(P>0.05);A、B、C、D组治疗后反酸、烧心改善总有效率分别为53.62%、80.56%、52.24%、87.14%,B、D组与A组,C组与D组比较均差异有统计学意义(P<0.05)。[结论]单用康复新对GU是有效的,适合轻中度GU;联合胶体果胶铋对GU更有效,适合较重的GU患者;再联合奥美拉唑对于GU最有效,特别适合重型GU患者。
- 胃溃疡 /
- 康复新液 /
- 胶体果胶铋 /
- 奥美拉唑
Abstract: [Objective] To compare the efficacy and safety of Kangfuxin Liquid combined with Colloidal Bismuth PECTin-739 and /or Omeprazole in the treatment of gastric benign ulcer(GU). [Methods] A total of 278 consecutive outpatients with GU were randomly divided into the following groups: group A treated with Kangfuxin Liquid, group B treated with Kangfuxin Liquid combined with Colloidal Bismuth PEC Tin-739, group C treated with Kangfuxin Liquid combined with Omeprazole, and group D treated with Kangfuxin Liquid combined with Colloidal Bismuth PECTin-739 and Omeprazole.Four weeks after treatment, the patients’ symptoms such as bellyache, epigastric distension, nausea, vomiting, sour regurgitation, heartburn as well as the adverse reactions were observed and recorded. [Results] The total effective rates for nausea and vomiting were 50.72%, 72.22%, 50.74%, and 75.71%., respectively in group A, B, C, and D after treatment, and the difference between group A and group B, group A and group D, group C and group D was statistically significant (P＜0.05).The total effective rates for bellyache and epigastric distension were 52.17%, 68.06%, 65.67%, and 95.71% respectively in group A, B, C, and D after treatment. There were significant differences between group A, B, C and group D (P＜0.05) The difference between group A and group B or group A and group C was insignificant (P>0.05) The total effective rates for sour regurgitation and heartburn were 53.62%, 80.56%, 52.24%, and 87.14%, respectively in group A, B, C, and D after treatment. The differences between group A and group B, between group A and group D, and between group C and group D were statistically significant (P＜0.05). [Conclusion] Kangfuxin Liquid was effective, suitable for mild GU.Kangfuxin Liquid combined with Colloidal Bismuth PECTin-739 has better effect on medium GU.Kangfuxin Liquid combined with Colloidal Bismuth PECTin-739 and /or Omeprazole is the most effective for GU, especially for severe GU.
- gastric benign ulcer /
- Kangfuxin Liquid /
- Colloidal Bismuth PECTin-739 /
- Omeprazole

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