疏肝和胃冲剂治疗非溃疡性消化不良的临床疗效

张竞超; 龙莎; 卢延年; 雷小兰; 李健; 张尚斌

doi:10.3969/j.issn.1671-038X.2013.02.004

疏肝和胃冲剂治疗非溃疡性消化不良的临床疗效

- 1. 广东深圳市中医院消化内科, 广东深圳 518033;
- 2. 广东深圳市中医院超声影像科, 广东深圳 518033;
- 3. 广东深圳市中医院药学部, 广东深圳 518033
基金项目:
广东深圳市科技计划项目（No：201003185）

详细信息

作者简介:
张竞超,主治医师,主要从事消化内科临床和研究工作

中图分类号: R723.1

收稿日期: 2012-10-15

Clinical study of Suganhewei instant granules on non-ulcer dyspepsia

- 1. Department of Digestive, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, China;
- 2. Ultrasonic Diagnosis Section Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, China;
- 3. Medicine Division, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, China

Received Date: 15 October 2012

摘要

摘要: [目的]探讨疏肝和胃冲剂治疗非溃疡性消化不良（NUD）的临床疗效。[方法]通过检测NUD患者经疏肝和胃冲剂、吗丁啉治疗前后血清胃泌素、胃动素及三维超声胃半排空时间，结合中医症状积分，综合评价2组药物的临床疗效。[结果]2组患者经药物治疗后症状总积分明显减少，血清胃泌素下降，胃动素升高，胃半排空时间缩短；与治疗前比较，差异有显著统计学意义（P<0.01）。疏肝和胃冲剂治疗后症状总积分及各项临床检测指标较吗丁啉治疗后改善更明显，差异有统计学意义（P<0.01）。[结论]疏肝和胃冲剂治疗NUD疗效可靠、无明显不良反应，具广泛的临床应用前景。
- 非溃疡性消化不良 /
- 胃排空 /
- 疏肝和胃冲剂
Abstract: [Objective] To evaluate the effect of traditional Chinese medicine Suganhewei instant granules (SIG) in improving gastric emptying of patients with non-ulcer dyspepsia(NUD).[Methods] One hundred and thirty patients of NUD were enrolled and treated with SIG (n=100) and domperidone (n=30) respectively for 4 weeks. The changes of TCM symptom scores, serum gastrin, plasma motilin, and half-time of liquid gastric emptying before and after treatment were observed.[Results] Compared with those before treatment, the TCM symptom scores were improved, level of serum gastrin was decreased and motilin was increased, half-time gastric emptying was shortened significantly after treatment (P<0.01). And the TCM symptom scores were improved much more significant in SIG group than in domperidone group (P<0.01).[Conclusion] The present study suggested that SIG could improve the gastric emptying in patients of NUD without side effects.
- non-ulcer dyspepsia /
- gastric emptying /
- Suganhewei instant granule

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