Advances in the study of the role of bile acids and their receptors in ulcerative colitis and traditional Chinese herbal medicine intervention
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摘要: 胆汁酸作为一类重要的微生物代谢物，在溃疡性结肠炎病程中发生改变，且与肠道微生物群之间存在密切关联。为进一步了解肠道微生物-胆汁酸-宿主轴对溃疡性结肠炎的影响，本文全面阐明胆汁酸合成、代谢及重吸收过程，并进一步综述溃疡性结肠炎中胆汁酸池改变以及其介导的信号传导。此外，我们通过总结中药介导胆汁酸改变治疗溃疡性结肠炎的研究进展，以期为溃疡性结肠炎的治疗提供新的见解。Abstract: Bile acids, an important class of microbial metabolites, are altered during the course of ulcerative colitis and are closely associated with the gut microbiota. To further understand the influence of the gut microbial-bile acid-host axis on ulcerative colitis, this article comprehensively elucidates the processes of bile acid synthesis, metabolism and reabsorption, and further reviews the altered bile acid pool and its mediated signaling in ulcerative colitis. In addition, we aim to provide new insights into the treatment of ulcerative colitis by summarizing the research progress of herbal medicine-mediated bile acid alterations in the treatment of ulcerative colitis.
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Key words:
- ulcerative colitis /
- bile acid /
- gut microbiota /
- traditional Chinese herbal medicine
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