Research progress of Traditional Chinese Medicine regulating intestinal microecology to relieve ulcerative colitis
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摘要: 溃疡性结肠炎(ulcerative colitis，UC)是肠道慢性迁延性疾病，其发病机制尚未明了，目前大量研究表明肠道微生态失衡是UC发病的重要调控因素。中药组方成分复杂，可从多个靶点、多条途径发挥对肠道微生态的调控作用，减轻炎症反应，保护肠黏膜屏障，在治疗UC方面疗效显著。本文综述了肠道菌群在UC发病机制中的作用，同时对中药通过调节肠道微生态缓解UC的研究进展进行总结，以期为UC治疗提供新策略，带来新机遇。Abstract: Ulcerative colitis(UC) is a chronic and persistent disease of the intestine, and its mechanisms remain elusive.Currently, a large number of studies have shown that intestinal microbiota imbalance is an important regulatory factor in the pathogenesis of UC.The composition of Traditional Chinese Medicine(TCM) is complex, and it can regulate the intestinal microbiota from multiple targets and pathways, reduce inflammation, protect the intestinal mucosal barrier, and have significant curative effects in the treatment of UC. This article reviews the role of gut microbiota in the pathogenesis of UC. Meanwhile, the research progress of alleviating UC by regulating intestinal microecology with TCM was summarized, to provide new strategies and bring new opportunities for UC treatment.
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