Effect of distance and moxibustion combined probiotics treatment on the microflora of children's emergency diarrhea
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摘要: 目的 探究苁蓉艾灸结合益生菌对急诊腹泻患儿肠道菌群的影响。方法 选取2022年4月—2023年3月收治的腹泻患儿共计70例。依照入院顺序编号，根据单双号分为对照组(单号)与试验组(双号)，其中对照组予以益生菌(双歧三联活菌片)治疗，试验组在对照组基础上结合苁蓉艾灸治疗，观察2组患儿治疗前后的酵母样真菌、肠球菌、乳酸菌数量、临床症状恢复情况及临床疗效。结果 试验组患儿治疗后的酵母样真菌数量明显少于对照组，而肠球菌、乳酸菌数量较对照组明显增加(P < 0.05)。试验组患儿大便性状复常时间、退热时间以及腹痛、呕吐消失时间均明显早于对照组(P < 0.05)。试验组临床总有效率高于对照组[94.29%(33/35) vs 82.86%(29/35)]，差异有统计学意义(P=0.041)。2组患儿在急诊治疗期间，皆未见有严重不良反应出现。结论 苁蓉艾灸结合益生菌治疗急诊小儿腹泻可明显缩短患儿症状消失时间，提高肠道有益菌数量，纠正肠道菌群失衡，该治疗方案临床疗效可观，且安全性高，值得在临床上应用与推广。Abstract: Objective To investigate the effect of distance and moxibustion combined probiotics treatment on the microflora of children with emergency diarrhea.Methods A total of 70 children who underwent diarrhea treatment from April 2022 to March 2023 were selected. According to the order of admission, they are divided into the control group(single number) and the test group (double number) according to the single and even numbers. According to the order of admission, they are divided into the control group (single number) and the test group(double number) according to the single and even numbers. The control group is treated with probiotics (bifid triple viable tablets). Based on the control group, the test group is treated with cistanche moxibustion, and the number of yeast-like fungi, enterococcus, and lactic acid bacteria before and after treatment clinical symptom recovery and clinical efficacy.Results After treatment, the number of yeast-like fungi in the test group was significantly less than that in the control group, while the number of enterococcus and lactic acid bacteria was significantly increased compared with that in the control group (P < 0.05). The recovery time of stool characteristics, fever reduction time, and disappearance time of abdominal pain and vomiting in the experimental group were earlier than those in the control group(P < 0.05). The total clinical effective rate of the experimental group was higher than that of the control group[94.29%(33/35) vs 82.86%(29/35)], and there was a significant difference between the groups(P=0.041). No serious adverse reactions occurred in the two groups during emergency treatment.Conclusion Cistanche moxibustion combined with probiotics in the treatment of emergency diarrhea in children can significantly shorten the time of symptom disappearance, increase the number of beneficial bacteria in the intestine, and correct the imbalance of intestinal flora. This treatment regimen has considerable clinical efficacy, and high safety, and is worthy of clinical application and promotion.
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Key words:
- pediatric diarrhea /
- cistanche moxibustion /
- probiotics /
- intestinal microbiota
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表 1 2组患儿肠道菌群数量比较
CFU/g，X±S 组别 例数 酵母样真菌 肠球菌 乳酸菌 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 试验组 35 4.18±0.54 3.29±0.381) 9.04±0.81 11.36±1.331) 8.39±0.45 9.82±0.851) 对照组 35 4.14±0.52 3.71±0.521) 9.08±0.83 10.17±1.221) 8.31±0.52 9.10±0.881) t 0.316 3.858 0.204 3.901 0.688 3.482 P 0.753 ＜0.001 0.839 ＜0.001 0.494 0.001 与治疗前比较，1)P < 0.05。 
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表 2 2组患儿临床症状恢复情况比较
d，X±S 组别 例数 大便性状复常时间 腹痛消失时间 呕吐消失时间 退热时间 试验组 35 2.58±0.75 2.15±0.42 1.82±0.32 1.52±0.34 对照组 35 3.12±1.12 2.58±1.02 2.13±0.62 1.90±0.52 t 2.370 2.306 2.629 2.666 P 0.021 0.024 0.011 0.010
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表 3 2组患儿临床疗效比较
例(%) 组别 例数 临床治愈 显效 有效 无效 总有效 试验组 35 21(60.00) 7(20.00) 5(14.29) 2(5.71) 33(94.29) 对照组 35 13(37.14) 9(25.71) 7(20.00) 6(17.14) 29(82.86) Z 2.045 P 0.041
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