黄竹欣胃汤辨证治疗肝胃郁热型胆汁反流性胃炎的临床疗效观察

李医芳; 朱叶珊

doi:10.3969/j.issn.1671-038X.2021.10.11

黄竹欣胃汤辨证治疗肝胃郁热型胆汁反流性胃炎的临床疗效观察

李医芳^,,
朱叶珊

- 唐山市中医医院脾胃病科(河北唐山, 063000)

详细信息

通讯作者: 李医芳,E-mail:yuanyqd8012@126.com

中图分类号: R256.3

收稿日期: 2021-05-07

Clinical efficacy of Huangzhu Xinwei Decoction in the differentiation treatment of bile reflux gastritis of liver-stomach heat stagnation

LI Yifang^,,
ZHU Yeshan

- Department of Spleen and Stomach Disease, Tangshan Hospital of Traditional Chinese Medicine, Tangshan, 063000, China

More Information

Corresponding author: LI Yifang, E-mail: yuanyqd8012@126.com

Received Date: 07 May 2021

摘要

摘要: 目的:探讨黄竹欣胃汤辨证治疗胆汁反流性胃炎(BRG)的临床效果。方法:随机将136例肝胃郁热型BRG患者分为对照组和观察组,每组68例,对照组给予常规西医治疗,观察组基于对照组治疗之上加予黄竹欣胃汤辅助治疗,评估2组治疗8周后的临床疗效,对比2组治疗前及治疗8周后的中医症状积分、胆汁反流情况(最长胆汁反流时间、胆汁反流次数、反流总时间占比)、血清胃泌素(GAS)及血浆胃动素(MTL)水平变化情况。结果:观察组的临床总有效率显著高于对照组(95.59%、85.29%,P<0.05);治疗8周后,2组胃脘疼痛、胃脘灼热、脘腹胀满、嗳气、胃中嘈杂、纳呆少食、烦躁易怒、体重减轻、便秘共9项中医症状积分及总积分较治疗前有显著降低(P<0.05),2组最长胆汁反流时间较治疗前有显著缩短(P<0.05),胆汁反流次数较治疗前有显著减少(P<0.05),反流总时间占比较治疗前有显著降低(P<0.05),2组血清GAS较治疗前有显著降低(P<0.05),血浆MTL水平较治疗前有显著性提升(P<0.05),观察组以上指标改善显著优于对照组(P<0.05)。结论:黄竹欣胃汤辅助西医治疗能提高肝胃郁热型BRG患者的临床疗效,可明显缓解中医症状,改善胆汁反流情况,并促进血清GAS及血浆MTL水平提高,以促进胃肠功能改善。
- 黄竹欣胃汤 /
- 胆汁反流性胃炎 /
- 血清胃泌素 /
- 血浆胃动素
Abstract: Objective: To investigate the clinical effect of Huangzhu Xinwei Decoction in the differentiation treatment of bile reflux gastritis(BRG).Methods: One hundred and thirty-six patients with BRG of liver-stomach stagnation-heat type were randomly divided into control group and observation group, with 68 cases in each group. The control group was treated with conventional western medicine, and the observation group was additionally treated with Huangzhu Xinwei Decoction based on the above. The clinical efficacy of the two groups was evaluated after 8 weeks of treatment, and the TCM symptoms scores, bile reflux status(the longest bile reflux time, frequency of bile reflux, the proportion of total reflux time) and levels of serum gastrin(GAS) and plasma motilin(MTL) were compared between the two groups before treatment and after 8 weeks of treatment.Results: The total clinical effective rate of observation group was significantly higher than that of control group(95.59%,85.29%, P<0.05). After 8 weeks of treatment, the scores of 9 items of TCM symptoms of stomach duct pain, gastric burning, abdominal fullness and distention, belching, noisy stomach, anorexia and poor appetite, anxiety and and irritability, weight loss and constipation and the total score in the two groups were significantly decreased compared with those before treatment(P<0.05), and the longest bile reflux time in the two groups was significantly shorter than that before treatment(P<0.05), and the frequency of bile reflux was significantly reduced compared to before treatment(P<0.05), and the proportion of total reflux time was significantly lower compared to before treatment(P<0.05), and the level of serum GAS in the two groups was significantly reduced compared with that before treatment(P<0.05) while the level of plasma MTL was significantly risen compared to before treatment(P<0.05), and the improvement status of the above indicators in observation group were significantly better than those in control group(P<0.05).Conclusion: Huangzhu Xinwei Decoction supplemented with western medicine can improve the clinical efficacy of patients with BRG of liver-stomach stagnation-heat type, can significantly relieve the TCM symptoms, improve bile reflux status, and promote the increases of serum GAS and plasma MTL to improve gastrointestinal function.
- Huangzhu Xinwei Decoction /
- bile reflux gastritis /
- serum gastrin /
- plasma motilin

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