术前纤维蛋白原与前白蛋白比值与食管癌患者病理特征关系及对其诊断价值的研究

冯晨曦; 费素娟

doi:10.3969/j.issn.1671-038X.2021.10.10

术前纤维蛋白原与前白蛋白比值与食管癌患者病理特征关系及对其诊断价值的研究

冯晨曦¹,
费素娟^2, ,

- 1. 徐州医科大学第一临床医学院(江苏徐州, 221002);
- 2. 徐州医科大学附属医院消化内科

详细信息

通讯作者: 费素娟,E-mail:xyfyfeisj99@163.com

中图分类号: R735.1

收稿日期: 2021-06-17

Study on the relationship between the ratio of fibrinogen to prealbumin before operation and the pathological characteristics of esophageal cancer patients and its diagnostic value

FENG Chenxi¹,
FEI Sujuan^2, ,

- 1. The First Clinical Medical College of Xuzhou Medical University, Xuzhou, 221000, China;
- 2. Department of Gastroenterology, Affiliated Hospital of Xuzhou Medical University

More Information

Corresponding author: FEI Sujuan, E-mail: xyfyfeisj99@163.com

Received Date: 17 June 2021

摘要

摘要: 目的:探讨术前纤维蛋白原与前白蛋白比值(FPR)与食管癌患者病理特征关系及其对食管癌的诊断价值。方法:选取2018年1月—2020年6月行食管癌根治术的患者200例,同时期住院治疗的食管良性疾病患者200例和胃镜检查未见明显异常的体检者200例。比较3组患者的纤维蛋白原和前白蛋白比值(FPR)、纤维蛋白原和白蛋白比值(FAR)、全身炎症反应指数(SIRI)、肿瘤标记物(CEA、CA19-9)的水平,通过Kruskal-Wallis、Mann-Whitney检验FPR、FAR、SIRI与食管癌患者临床病理特征的相关性,通过Logistic回归分析食管良恶性疾病鉴别诊断的危险因素,利用ROC曲线评价FPR、FAR、SIRI、CEA、CA19-9对食管癌患者的诊断及良恶性患者的鉴别诊断。结果:食管癌组患者术前FPR、FAR、SIRI、CEA、CA19-9均显著高于食管良性疾病组、健康对照组(P<0.01);FPR、FAR、SIRI、CEA、CA19-9在食管良性疾病组与健康对照组比较,差异无统计学意义(P>0.05);通过Kruskal-Wallis、Mann-Whitney检验对食管癌患者临床病理特征分析显示,随着淋巴结转移、浸润深度加深、肿瘤最大直径增加、临床分期的增加,食管癌患者的FPR、FAR、SIRI的中位数显著升高,而与肿瘤的位置、分化程度、神经或脉管侵犯无明显的相关性。Logistic回归分析显示,FPR、SIRI、CEA与食管癌和食管良性疾病的鉴别诊断显著相关。ROC曲线分析结果显示,FPR、FAR对食管癌的诊断效能显著高于其他指标。结论:FPR可能是诊断食管癌有价值的生物标记物,其可提高食管癌和食管良性疾病的鉴别诊断效率。
- 食管癌 /
- 纤维蛋白原与前白蛋白的比值 /
- 纤维蛋白与白蛋白的比值 /
- 全身炎症反应指数 /
- 病理特征 /
- 诊断
Abstract: Objective: To study the relationship between preoperative fibrinogen/pre-albumin ratio(FPR) and pathological characteristics of esophageal cancer and its diagnostic value for esophageal cancer.Methods: Two hundred patients who underwent radical esophagectomy in Xuzhou Medical University from January 2018 to June 2020, 200 patients with benign esophageal diseases who were hospitalized in our hospital at the same time, and 200 physical examinees who had no obvious abnormality in gastroscopy were selected. The levels of FPR, FAR, SIRI, CEA and CA19-9 in the three groups were compared. Kruskal-Wallis and Mann-Whitney were used to test the correlation between FPR, FAR and SIRI and clinicopathological features of esophageal cancer patients. Logistic regression was used to analyze the risk factors of differential diagnosis of esophageal diseases. ROC curve was used to evaluate the diagnosis of FPR, FAR, SIRI, CEA and CA19-9 in esophageal cancer patients and differential diagnosis of benign and malignant patients.Results: The FPR, FAR, SIRI, CEA and CA19-9 of patients with esophageal cancer before operation were significantly higher than those of patients with benign esophageal diseases and healthy controls(P<0.01). FPR, FAR, SIRI, CEA, CA19-9 showed no significant difference between benign esophageal disease group and healthy control group(P>0.05). The analysis of clinicopathological features of esophageal cancer patients by Kruskal-Wallis and Mann-Whitney test showed that the median FPR, FAR and SIRI of esophageal cancer patients increased significantly with lymph node metastasis, deeper invasion depth, larger tumor diameter and increased clinical stage, but had no obvious correlation with tumor location, differentiation degree and nerve or vessel invasion. Logistic regression showed that FPR, SIRI and CEA were significantly related to the differential diagnosis of esophageal cancer and benign esophageal diseases. ROC curve analysis showed that FPR and FAR were significantly more effective in diagnosing esophageal cancer than other indicators.Conclusion: The ratio of fibrinogen to prealbumin(FPR) may be a valuable biomarker for the diagnosis of esophageal cancer, which can improve the differential diagnosis efficiency between esophageal cancer and benign esophageal diseases.
- esophageal cancer /
- fibrinogen to prealbumin ratio /
- fibrinogen to prealbumin ratio /
- systemic inflammation response index /
- pathological characteristics /
- diagnosis

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