Effect of modified Baitouweng decoction combined with maizulin-S enema on the regulation of inflammatory response and immune function in ulcerative colitis patients
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摘要: 目的:探讨改良白头翁汤结合麦滋林-S灌肠调节溃疡性结肠炎(UC)患者机体炎症反应及免疫功能的影响。方法:选择2017年1月—2020年1月收治的156例UC患者,随机数表法将患者分为观察组和对照组2组,每组各78例。对照组行麦滋林-S灌肠,观察组行改良白头翁和麦滋林-S灌肠。对比、评估并分析2组患者中医证候积分、临床总有效率、血清炎症指标、肠道菌群分布、免疫功能和安全性等参数。结果:治疗后,观察组患者临床总有效率高于对照组。2组患者中医证候积分、炎性因子明显降低,且观察组患者中医证候积分和炎性因子明显低于对照组(P<0.05);2组患者肠道双歧杆菌、乳酸杆菌及真杆菌数量明显提高,2组患者肠道肠杆菌和肠球菌等数量明显降低,且观察组患者肠道双歧杆菌、乳酸杆菌及真杆菌数量高于对照组,观察组患者肠道肠杆菌和肠球菌等数量明显低于对照组(P<0.05)。2组患者CD3+CD4+%和CD4+/CD8+明显提高,CD3+CD8+%明显降低;且观察组患者CD3+CD4+%和CD4+/CD8+明显高于对照组(P<0.05),观察组患者CD3+CD8+%显著低于对照组(P<0.05)。治疗期间,2组患者未见恶心、呕吐及头痛等不良反应。结论:改良白头翁汤结合麦滋林-S灌肠可有效改善患者中医证候积分,提高临床疗效,降低炎症反应,增强免疫功能,安全性好,值得临床进一步研究和推广。Abstract: Objective: To study the effect of modified Baitouweng decoction combined with maizulin-S enema on the regulation of inflammatory response and immune function in ulcerative colitis patients.Methods:A total of 156 patients with UC admitted to Tangshan Fengrun District People's Hospital from January 2017 to January 2020 were selected and divided into observation group and control group, with 78 patients in each group.Control group was treated with maizulin-S enema, while observation group was treated with modified pulsatilla chinensis on the basis of control group.The TCM syndrome score, clinical total effective rate, serum inflammatory indexes, intestinal microflora distribution, immune function and adverse reactions were compared between the two groups.Results:After treatment, the Traditional Chinese Medicine(TCM)syndrome score in 2 groups was significantly decreased, and the TCM syndrome score in observation group was significantly lower than that in control group(P<0.05);The total effective rate of observation group was significantly higher than that of control group(P<0.001).The levels of serum inflammatory factors such as IL-23,IL-17 and TNF-α in 2 groups were significantly decreased, and the levels of serum inflammatory factors such as IL-23,IL-17 and TNF-α in observation group were significantly lower than those in control group(P<0.05).The number of Bifidobacteria, Lactobacillus and Enterobacteria in 2 groups was significantly increased, and the number of Enterobacteria and Enterococcus in 2 groups was significantly decreased, and the number of Bifidobacteria, Lactobacillus and Enterococcus in observation group was higher than that in control group, and the number of Enterobacteria and Enterococcus in observation group was significantly lower than that in control group(P<0.05).The proportions of CD3+CD4+and CD4+/CD8+in 2 groups were significantly increased, while the proportions of CD3+CD8+in 2 groups were significantly decreased; The proportion of CD3+CD4+and CD4+/CD8+in observation group was significantly higher than that in control group(P<0.05),and the proportion of CD3+CD8+in observation group was significantly lower than that in control group(P<0.05).During the treatment, no adverse reactions such as nausea, vomiting and headache were observed in the two groups.Conclusion:The combination of modified Baitouweng decoction and maizulin-S enema could effectively improve patients' TCM symptom scores and clinical efficacy, reduce inflammatory response, enhance immune function, and it is safe, which is worthy of further clinical research and promotion.
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Key words:
- modified Baitouweng Decoction /
- maizulin-S enema /
- ulcerative colitis /
- inflammation /
- immune function
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