Clinical study of modified Huangqi decoction combined with compound lactobacillus acidophilus in the treatment of constipation of Qi deficiency after chemotherapy
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摘要: 目的：以加减黄芪汤联合复方嗜酸乳杆菌治疗肿瘤化疗后便秘（气虚证），观察疗效。方法：90例肿瘤化疗后气虚型便秘患者，随机分为联合组、中药组、西药组，分别以加减黄芪汤联合复方嗜酸乳杆菌、加减黄芪汤、复方嗜酸乳杆菌治疗，比较3组便秘中医症状评分、肠道菌群、便秘临床症状评分（CCS）、生存质量评分（PAC-QOL）及肿瘤功能状态评分（KPS）。结果：治疗后，3组便秘中医症状评分、CCS、PAC-QOL评分均降低，肠道菌群中双歧杆菌、乳杆菌均升高，大肠杆菌、肠球菌降低，联合组均优于其他2组，差异有统计学意义（P<0.05）；联合组、中药组KPS评分升高，与西药组比较差异有统计学意义（P<0.05）；联合组总有效率为93.3%，高于其他2组（中药组为73.3%，西药组为60.0%），均差异有统计学意义（P<0.05）。结论：加减黄芪汤与复方嗜酸乳杆菌联合治疗化疗后便秘，能重整肠道菌群，改善便秘，提高肿瘤患者的生存质量。Abstract: Objective: Modified Huangqi decoction combined with compound lactobacillus acidophilus was used to treat constipation (Qi deficiency syndrome) after chemotherapy. Methods: Ninety patients with constipation of qi deficiency type after chemotherapy were randomly divided into combined group, traditional Chinese medicine group and western medicine group. The patients were treated with modified Huangqi decoction combined with compound lactobacillus acidophilus, modified Huangqi decoction and compound lactobacillus acidophilus, respectively.The traditional Chinese Medicine symptoms, intestinal flora, clinical symptom score of constipation (CCS), quality of life score of constipation (PAC-QOL) and tumor functional status score (KPS) in the three groups were compared.Results: After treatment, constipation symptoms, CCS and PAC-QOL scores were all decreased in the three groups; Bifidobacterium and lactobacillus in intestinal flora were increased, escherichia coli and enterococcus were decreased, and the combined group was better than the other two groups, with statistical significance (P<0.05). The KPS score of combined group and traditional Chinese medicine group was increased, and the difference was statistically significant compared with that of western medicine group (P <0.05). The total effective rate of the combined group was 93.3%, which was higher than that of the other two groups (73.3% in the traditional Chinese medicine group, 60.0% in the western medicine group), with statistical significance (P<0.05). Conclusion: Conclusion:The combination of modified Huangqi Decoction and compound lactobacillus acidophilus in the treatment of constipation after chemotherapy can restructure intestinal flora, improve constipation and improve the quality of life of tumor patients.
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