Application of polycarbophil calcium combined with simethicone oil and polyethylene glycol electrolyte powder on bowel preparation for colonoscopy in patients with chronic constipation
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摘要: 目的：探讨聚卡波非钙联合西甲硅油与聚乙二醇电解质散（PEG）在慢性便秘患者肠镜检查前肠道准备中的有效性和安全性。方法：采用随机、单盲、前瞻性的研究方法，将2020年3月-12月于徐州医科大学附属医院接受肠镜检查的慢性便秘患者共252例随机均分为A、B、C 3个组，分别采用聚卡波非钙+西甲硅油+PEG（A组）、聚卡波非钙+PEG（B组）、PEG（C组）的清肠方案。分别比较3组方案的肠道清洁效果（Boston评分和祛泡效果）、病变检出率、进退镜时间、不良事件和严重不良事件的发生率。采用SPSS 26.0软件进行统计分析。结果：由于9例中途退出研究，该研究最终纳入243例患者。A、B组Boston评分各段及总评分优于C组（P<0.05），A组患者病变检出率高于B、C组（P<0.05），A组方案祛泡效果明显优于B、C组（P<0.05），A组患者进镜和退镜时间短于C组和B组。在不良反应方面，A组方案可减轻患者腹胀的发生率（P<0.05），但在恶心呕吐、腹痛及其他严重不良反应事件的发生率上3个组差异无统计学意义。结论：聚卡波非钙联合西甲硅油与PEG在慢性便秘肠镜检查肠道准备上存在优势，有利于改善视野，提高病变检出率，缩短结肠镜检查时间，减少腹胀的发生率，从而减轻患者痛苦，提高检查效率。Abstract: Objective: To observe the efficacy and safety of polycarbophil calcium combined with simethicone oil and polyethylene glycol electrolyte powder(PEG) in bowel preparation before colonoscopy in patients with chronic constipation. Methods: This study included 252 constipation patients receiving colonoscopy in Aaffiliated Hospital of Xuzhou Medical University from March to December 2020. The patients were randomly divided into group A, B and C, respectively using polycarbophil calcium + simethicone oil + PEG(group A), polycarbophil calcium + PEG(group B), PEG(group C) colon cleansing solution. The intestinal cleaning effects(Boston score and foaming removal effect), the lesion detection rate, the insertion time and withdraw time, adverse events and serious adverse events of the three groups were compared respectively. SPSS 26.0 was used for statistical analysis, and P<0.05 was considered statistically significant. Results: Two hundred and forty-three patients were eventually included. The BBPS score of the group A and B was higher than that of the group C, and the difference was statistically significant(P<0.05). The lesion detection rate of group A was higher than that of group B and C(P<0.05). The foaming removal effect of group A was significantly better than that of group B and C(P<0.05). The group A had shorter insertion time and withdraw time than the other two groups. In terms of adverse reactions, the group A can reduce the incidence of abdominal distension in patients(P<0.05), but no significant difference was observed in the incidence of nausea and vomiting, abdominal pain and other serious adverse events between the three groups. Conclusion: The application of polycarbophil calcium combined with simethicone oil and PEG for colonoscopy in constipation patients can improve visual field, improve the detection rate of lesions, shorten colonoscopy examination time, reduce the incidence of abdominal distension, thus reducing patient pain and improving examination efficiency.
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