甘草泻心汤联合美沙拉嗪对溃疡性结肠炎患者疗效及肠道菌群和血清炎症因子水平的影响

沈灵娜; 刘军; 钱赟达; 熊烈

doi:10.3969/j.issn.1671-038X.2021.07.06

甘草泻心汤联合美沙拉嗪对溃疡性结肠炎患者疗效及肠道菌群和血清炎症因子水平的影响

- 嘉兴市中医医院脾胃病科(浙江嘉兴, 314000)
基金项目:
浙江省嘉兴市科技计划项目（No：2018AD32123）

详细信息

通讯作者: 沈灵娜,E-mail:mmmmy12345@163.com

中图分类号: R574.62

收稿日期: 2021-01-31

Efficacy of Gancao Xiexin Decoction combined with mesalazine on patients with ulcerative colitis, and the influence of intestinal flora and serum inflammatory factors

- Department of Spleen and Stomach Diseases, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, 314000, China

More Information

Corresponding author: SHEN Lingna, E-mail: mmmmy12345@163.com

Received Date: 31 January 2021

摘要

摘要: 目的：观察和分析甘草泻心汤联合美沙拉嗪对溃疡性结肠炎（UC）患者的疗效及对肠道菌群和血清炎症因子水平的影响。方法：将符合纳入标准的60例寒热错杂型UC患者随机分为2个组，对照组（30例）给予口服美沙拉嗪肠溶片治疗；中药组（30例）在相同西药治疗基础上加用甘草泻心汤口服。观察2组治疗后的中医证候疗效及中医症状积分、临床疗效及改良Mayo活动指数，并检测肠道菌群（包括双歧杆菌、乳杆菌、大肠杆菌）及血清炎症因子的变化。结果：中药组的中医证候疗效总有效率、临床疗效有效率均高于对照组（P<0.05）；2组患者治疗后，其中医症状积分、改良Mayo活动指数、IL-6、TNF-α水平较治疗前均明显降低（P<0.05）；2组IL-10较治疗前均升高（P<0.05）；2组患者双歧杆菌、乳杆菌数量均较治疗前增多，大肠杆菌数量较治疗前减少（P<0.05）；且上述疗效中药组均优于对照组（P<0.05）。结论：在西药治疗基础上加用甘草泻心汤口服，可有效改善寒热错杂型UC患者的临床症状，其或许是通过增加肠道有益菌、调节肠道菌群结构、减轻机体炎症反应而达到治疗效果。
- 甘草泻心汤 /
- 溃疡性结肠炎 /
- 肠道菌群 /
- 血清炎症因子
Abstract: Objective: To observe and analyze the effect of Gancao Xiexin Decoction combined with mesalazine on patients with ulcerative colitis(UC) and the effect on intestinal flora and serum inflammatory factor levels. Methods: Totally 60 patients with UC of complicated cold and heat syndrome were randomized into 2 groups, the control group(n=30):oral mesalazine enteric-coated tablets; the Traditional Chinese Medicine group((n=30):in the base of the treatment of the control group, we add patients with Gancao Xiexin Decoction for oral administration.Observe the efficacy of Traditional Chinese Medicine symptoms and Traditional Chinese Medicine symptom scores, clinical efficacy and modified Mayo activity index after treatment in the two groups, and detect the changes of intestinal flora(including Bifidobacterium, Lactobacillus, Escherichia coli) and serum inflammatory factors. Results: The total effective rate of Traditional Chinese Medicine symptom curative effect and the effective rate of clinical curative effect in the Traditional Chinese Medicine group were higher than those in the control group(P<0.05); after treatment in the two groups, the medical symptom score, modified Mayo activity index, serum interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) levels were significantly lower than before treatment(P<0.05);and the interleukin-10(IL-10) in the two groups were both higher than before treatment(P<0.05);the numbers of Bifidobacteria and Lactobacilli in the two groups increased compared with before treatment, and the number of Escherichia coli decreased compared with before treatment(P<0.05), and the above-mentioned curative effect Traditional Chinese Medicine group is better than the control group(P<0.05). Conclusion: The above results show that the addition of Gancao Xiexin Decoction on the basis of western medicine can effectively improve the clinical symptoms of patients with UC of complicated cold and heat syndrome.It may achieve the therapeutic effect by increasing the beneficial bacteria in the intestine, adjusting the structure of the intestinal flora, and reducing the body's inflammatory response.
- Gancao Xiexin Decoction /
- ulcerative colitis /
- intestinal flora /
- serum inflammatory factors

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