加味三黄泻心汤联合艾司奥美拉唑、阿莫西林及铋剂治疗Hp的临床研究

徐珊; 李岩

doi:10.3969/j.issn.1671-038X.2021.05.08

加味三黄泻心汤联合艾司奥美拉唑、阿莫西林及铋剂治疗Hp的临床研究

徐珊,
李岩^,

- 中国医科大学附属盛京医院消化内科(沈阳, 110004)

详细信息

通讯作者: 李岩,E-mail:yanli0227@126.com

中图分类号: R573.6

收稿日期: 2021-01-31

Clinical study of modified Sanhuang Xiexin decoction combined with esomeprazole, amoxicillin and Potassium bismuth citrate in the treatment of Helicobacter pylori

XU Shan,
LI Yan^,

- Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, 110004, China

More Information

Corresponding author: LI Yan, E-mail: yanli0227@126.com

Received Date: 31 January 2021

摘要

摘要: 目的:比较加味三黄泻心汤联合艾司奥美拉唑、阿莫西林、枸橼酸铋钾与含克拉霉素标准四联疗法治疗Hp的疗效。方法:选取消化内科门诊85例经¹³C-尿素呼气试验(¹³C-UBT)证实Hp感染并伴有相关临床症状的患者。随机分成2组,A组予加减三黄泻心汤联合艾司奥美拉唑、阿莫西林、枸橼酸铋钾方案;B组予含克拉霉素标准四联方案,予以Hp根除治疗。结果:A组Hp根除率为82.22%,B组Hp根除率为82.50%,2组差异无统计学意义(P>0.05)。A组临床症状改善率为81.85%,优于B组(63.44%),差异有统计学意义(P<0.05)。A组不良反应发生率为6.67%,低于B组(52.50%),差异有统计学意义(P<0.05)。结论:加味三黄泻心汤替代传统铋剂四联艾司奥美拉唑、阿莫西林、克拉霉素及枸橼酸铋钾中克拉霉素在根除Hp治疗方面与含克拉霉素效果相当,并能更好地改善患者的临床症状,且不良反应发生率低,患者依从性好,特别对克拉霉素高耐药地区Hp的根除治疗提供了新的根除治疗方案。
- 三黄泻心汤 /
- 克拉霉素 /
- 幽门螺杆菌
Abstract: Objective: To compare the efficacy of modified Sanhuang Xiexin decoction combined with esomeprazole, amoxicillin, Potassium bismuth citrate with clarithromycin standard quadruple regimen in the treatment of Helicobacter pylori(Hp).Methods: Eighty-four patients with Hp infection confirmed by ¹³C-urea breath test(¹³C-UBT) and associated clinical symptoms were selected. Group A was treated with modified Sanhuang Xiexin decoction combined with esomeprazole, amoxicillin and Potassium bismuth citrate, Group B was treated with clarithromycin standard quadruple regimen, Hp eradication treatment was given.Results: Hp eradication rate of group A(82.22%), group B(82.50%), and the difference was not statistically significant(P>0.05). The improvement rate of clinical symptoms in group A(81.85%) was better than that in group B(63.44%), and the difference was statistically significant(P<0.05). The incidence of adverse reactions in group A(6.67%) was lower than that in group B(52.50%), and the difference was statistically significant(P<0.05).Conclusion: Modified Sanhuang Xiexin decoction can replace clarithromycin in the standard quadruple regimen, which has the same effect as clarithromycin in the eradication of Hp, and can better improve the clinical symptoms of patients, with low incidence of adverse reactions and good patient compliance, especially for the eradication of Hp in clarithromycin resistant areas Treatment provides a new eradication treatment.
- modified Sanhuang Xiexin decoction /
- clarithromycin /
- Helicobacter pylori

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