健脾解毒方联合西医三联疗法对幽门螺杆菌诱导的胃溃疡患者的临床疗效及幽门螺杆菌清除率的影响

曾韦苹; 马红丽; 努尔沙娜

doi:10.3969/j.issn.1671-038X.2019.09.07

健脾解毒方联合西医三联疗法对幽门螺杆菌诱导的胃溃疡患者的临床疗效及幽门螺杆菌清除率的影响

- 克拉玛依市人民医院(中医医院) 普通内科, 新疆克拉玛依 834000

详细信息

作者简介:
曾韦苹,女,硕士研究生,住院医师,研究方向:中西医结合消化

通讯作者: 曾韦苹,E-mail:yyy2018520@sina.com

中图分类号: R573.1

收稿日期: 2019-05-25

Effect of Jianpi jiedu recipe combined with western medicine triple therapy on clinical efficacy and Hp clearance rate of patients with gastric ulcer induced by Hp

- Department of Medicine, People's Hospital of Karamay(Traditional Chinese Medicine Hospital), Karamay 834000, China

More Information

Corresponding author: CENG Wei-ping, E-mail: yyy2018520@sina.com

Received Date: 25 May 2019

摘要

摘要: [目的]探究健脾解毒方联合西医三联疗法对, 幽门螺杆菌 (Hp) 诱导的胃溃疡患者的临床疗效及Hp清除率的影响。[方法]采集2018年1月~2018年12月我院收治的102例胃溃疡患者, 按照随机数字法分为观察组和对照组各51例, 对照组采用三联法治疗, 观察组采用健脾解毒方联合三联法治疗, 观察治疗前后临床疗效, Hp根除率, 胃蛋白酶原 (PG) 含量, 胃泌素 (GAS), 胃动素 (MTL), 胃窦溃疡直径, 胃体溃疡直径和胃黏膜TFF1蛋白表达水平。[结果]治疗后观察组临床总有效率96.08%显著高于对照组80.39%, Hp根除率86.24%显著高于对照组68.63%, 复发率3.92%显著低于对照组15.69%, 差异有统计学意义 (P<0.05);治疗后2组胃窦溃疡直径、胃体溃疡直径、GAS、PG和胃黏膜TFF1蛋白表达水平均下降, 且观察组低于对照组, 差异有统计学意义 (P<0.05);2组MTL含量治疗前后、组间比较差异均无统计学意义 (P>0.05)。[结论]健脾解毒方联合西医三联法治疗Hp诱导胃溃疡能有效根除Hp, 提高临床疗效, 降低复发率, 是一种切实可行的治疗方法。
- 健脾解毒方 /
- 三联法 /
- Hp /
- 胃溃疡
Abstract: [Objective]To explore the effect of Jianpi Jiedu recipe combined with triple therapy of Western Medicine on clinical efficacy and Hp clearance rate of Hp-induced gastric ulcer patients.[Methods]102 patients with gastric ulcer admitted to our hospital from January 2018 to December 2018 were randomly divided into observation group and control group with 51 cases in each group.The control group was treated with triple therapy while the observation group was treated with Jianpi Jiedu recipe combined with triple therapy.The clinical efficacy, eradication rate of Helicobacter pylori (Hp), content of pepsinogen (PG), gastrin (GAS), Motilin (MTL), diameter of gastric antrum ulcer, diameter of gastric body ulcer and expression of TFF1 protein in gastric mucosa were observed before and after the treatment.[Results]After the treatment, the total clinical effective rate of the observation group (96.08%) was significantly higher than that of the control group (80.39%), the eradication rate of Hp (86.24%) was significantly higher than that of the control group (68.63%), the recurrence rate (3.92%) was significantly lower than that of the control group (15.69%) and the difference was statistically significant (P<0.05);The diameter of gastric antral ulcer, the diameter of gastric body ulcer, the expression level of GAS, PG and TFF1 protein in gastric mucosa of two groups were both decreased after the treatment while experimental group was more effective with statistical difference;There was no significant difference in MTL content between the two groups before and after treatment (P>0.05).[Conclusion]Jianpi Jiedu Decoction combined with triple therapy of Western medicine is a feasible treatment method since it can effectively eradicate Hp induced gastric ulcer, improve clinical efficacy and reduce recurrence rate.
- Jianpi Jiedu Formula /
- triple method /
- Hp /
- gastric ulcer

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