柴芍六君子汤联合PegIFNα-2a治疗HBeAg阳性慢性乙型肝炎的临床观察

吕建林; 毛德文; 张荣臻; 宁碧泉; 柳琳琳

doi:10.3969/j.issn.1671-038X.2018.02.06

柴芍六君子汤联合PegIFNα-2a治疗HBeAg阳性慢性乙型肝炎的临床观察

- 1 广西中医药大学第一附属医院, 广西南宁 530023;
- 2 广西中医药大学, 广西南宁 530001
基金项目:
国家“十一五”科技重大专项项目(No:2008ZX10005-007)

国家科技重大专项课题(No:2012ZX10005004-003)

广西壮族自治区卫生和计划生育委员会自筹经费科研课题(No:Z2015472)。

详细信息

作者简介:
吕建林,男,副主任医师,硕士,研究方向:中西医结合防治肝病

通讯作者: 柳琳琳,E-mail:1045169864@qq.com

中图分类号: R512.6+2

收稿日期: 2017-03-28

Observation on chronic viral hepatitis B treated with Chaishao Liujunzi decoction combined with interferon alpha-2a

- 1 The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China;
- 2 Pharmacy School, Guangxi University of Chinese Medicine, Nanning 530001, China

More Information

Corresponding author: LIU Lin-lin, E-mail: 1045169864@qq.com

Received Date: 28 March 2017

摘要

摘要: [目的]观察柴芍六君子汤联合聚乙二醇干扰素(PegIFNα-2a)治疗HBeAg阳性慢性乙型性肝炎的临床疗效。[方法]将90例符合纳入标准的患者按照随机数字表法分为试验组47例和对照组43例,对照组予PegIFNα-2a治疗,试验组在对照组基础上给加用柴芍六君子汤治疗,治疗24周为1个疗程。通过评价2组肝功能(ALT、AST)情况、HBeAg阴转率、HBV-DNA阴转率、HBeAg血清学转换率、临床症状改善、不良反应发生率等观察柴芍六君子汤联合PegIFNα-2a疗效。[结果]试验组在降低转氨酶、HBeAg阴转率、HBV-DNA阴转率、HBeAg血清学转换率、临床症状改善、不良反应发生率方面均优于对照组(P＜0.05)。[结论]柴芍六君子汤可提高PegIFN-α2a治疗HBeAg阳性慢性乙型肝炎的抗病毒疗效,改善生活质量,减少PegIFNα-2a不良反应。
- 慢性乙型肝炎 /
- 柴芍六君子汤 /
- PegIFNα-2a
Abstract: [Objective] To observe the Chaishao Liujunzi decoction combined with PegIFNα-2 aon chronic viral hepatitis B.[Methods] 90 cases were randomlydivided into experimental group(47 cases)and the control group(43 cases).The control group were given PegIFNα-2 a,while the experimental group were treated by Chaishao Liujunzi decoction combined PegIFNα-2 a.The treatment lasted 24 weeks.Clinical efficacy was observed by assessing ALT,HBeAg negative conversion rate,HBV DNA negative conversion rate,HBeAg serological conversion rate,improvement of clinical symptoms,and adverse effects rate.[Results] Better effects were achieved in experimental group on reduced transaminase,HBeAg negative conversion rate,HBV DNA negative conversion rate,HBeAg serological conversion rate,and improvement of clinical symptoms.Adverse effects rate was lower than that of control group.[Conclusion] Chaishao Liujunzi decoction can improve the antiviral efficacy of PegIFNα-2 ain treating HBeAg positive chronic hepatitis B,improve quality of life,and reduce adverse reaction of PegIFNα-2 a.
- chronic viral hepatitis B /
- Chaishao Liujunzi decoction /
- interferon alpha-2a

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