辛开苦降法联合奥美拉唑治疗60例胃食管反流病临床观察

刘登科; 张婧; 席晓如; 魏玮

doi:10.3969/j.issn.1671-038X.2018.02.05

辛开苦降法联合奥美拉唑治疗60例胃食管反流病临床观察

- 1 中国中医科学院望京医院脾胃病科, 北京 100102;
- 2 中国中医科学院眼科医院检验科, 北京 100040;
- 3 北京市西城区西长安街社区卫生服务中心, 北京 100031
基金项目:
国家自然基金面上项目(No:81273746)。

详细信息

作者简介:
刘登科,男,主治医师,研究方向:中西医结合防治脾胃病

通讯作者: 张婧,E-mail:736494076@qq.com

中图分类号: R256.3

收稿日期: 2017-09-07

Clinical study of Xinkaikujiang method combined with Omeprazole in treating gastroesophageal reflux disease

- 1 Department of Gastroenterology, Wangjing Hospital, China Academy of Chinese Medical Science, Beijing 100102, China;
- 2 Department of Laboratory, Eye Hospital, China Academy of Chinese Medical Science, Beijing 100040, China;
- 3 Communit Health, Service Center of West Chang'an, Beijing 100031, China

More Information

Corresponding author: ZHANG Jing, E-mail: 736494076@qq.com

Received Date: 07 September 2017

摘要

摘要: [目的]观察辛开苦降法对胃食管反流病(GERD)患者临床症状及心理状态的干预效果。[方法]收集60例GERD患者,并随机分为对照组和治疗组。对照组予奥美拉唑,治疗组在此基础上联合辛开苦降方,疗程为8周。以反流性疾病问卷量表(RDQ)、胃镜检查、焦虑自评量表(SAS)和抑郁自评量表(SDS)对疗效进行评估。[结果]2组治疗后RDQ各症状积分及总分均明显下降(P＜0.01),且治疗组下降更为显著;治疗后2组总体有效率分别为90.0%和70.0%,镜下有效率分别为90.9%和70.8%,治疗组均优于对照组(P＜0.05);治疗后治疗组SAS和SDS积分均明显低于对照组(P＜0.05)。[结论]辛开苦降法联合奥美拉唑治疗8周后可有效缓解烧心、反酸等症状,改善焦虑、抑郁状态,其疗效明显优于单独奥麦拉唑治疗。
- 胃食管反流病 /
- 辛开苦降 /
- 焦虑 /
- 抑郁
Abstract: [Objective] To observe the efficacy of Xinkaikujiang method in improving the symptoms and psychological states of gastroesophageal reflux disease.[Methods] Sixty GERD patients were recruited and randomly divided into experimental group and control group.The experimental group received Xinkaikujiang formula combined with Omeprazole,while Omeprazole was used alone in the control group.Both groups were treated for 8 weeks.The reflux diagnostic questionnaire(RDQ)was utilized to assess the reflux symptoms.Gastroscopy was performed to evaluate the inflammation of eosphguas.The self-rating anxiety scale(SAS)and self-rating depression scale(SDS)were used as the assessments of anxiety and depression.[Results] After 8-weeks treatment,the RDQ scores of the two groups were significantly decreased(P＜0.05).Additionally,the score of the experimental group was much lower than the control group(P＜0.05).The total effective rate of the experimental group was 90.0%,superior to the control group 70.0% (P＜0.05).The total effective rate under the gastroscopy of the experimental group was 90.9%,superior to the control group 70.8% (P＜0.05).For SAS and SDS,the trial group had a greater decrease in scores.[Conclusion] Xinkaikujiang method combined with Omeprazole could effectively alleviate the symptoms such as heartburn,acid reflux,improve the state of anxiety and depression.The combined therapy showed a superior curative effect than the single therapy.
- gastroesophageal reflux disease /
- Xinkaikujiang /
- anxiety /
- depression

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