Abstract: [Objective] To observe the blood coagulation state changes in chronic recurrent ulcerative colitis patients and the effect of Yiqi Jiedu Huayu recipe on UC.[Methods] 60 patients with UC were randomly divided into the treatment group(Yiqi Jiedu Huayu recipe combined Mesalazine Granules) and the control group(Mesalazine Granules).30 cases in each group.After the treatment of one month, the symptom changes, disease activity index, endoscopic grade index, ESR, CRP and the blood coagulation index(PLT, MPV, FIB, D-D, PT) of UC were observed.[Results] The effective rate of treatment group was higher than that of control group, the difference was statistically significant(P<0.01).The treatment group could improve the symptoms of mucous purulent blood, tenesmus, better than that in control group, the difference was statistically significant(P<0.05 or P<0.01).Compared with control group, the Mayo and Baron score of treatment group were significantly reduced after treatment, the difference was statistically significant(P< 0.01).The level of ESR, CRP, PLT, FIB, D-D of treatment group were significantly reduced after treatment., the difference was statistically significant(P<0.05 or P<0.01).The level of MPV and PT were statistically higher after treatment, the difference was statistically significant(P<0.05 or P<0.01).[Conclusion] Yiqi Jiedu Huayu recipe can improve the clinical efficacy of UC and can significantly improve the disease activity index, endoscopic grade, ESR, CRP in chronic recurrent of UC patients.And Yiqi Jiedu Huayu recipe can improve blood coagulation state of UC patients by increasing the level of serum MPV, reducing the level of serum PLT, prolonging PT and reducing the level of plasma FIB, D-D, ESR, CRP.