Abstract: [Objective] To explore the clinical treatment and therapeutic effect of combined traditional Chinese medicine and western medicine in the treatment of atrophic gastritis.[Methods] 200 patients were treated for atrophic gastritis from January 2014 to January 2016, and equally divided into observation group and control group according to different treatment methods.The patients in the observation group were treated with Western medicine combined with traditional Chinese medicine, the control group of patients with simple Western medicine treatment.We compared the two groups of patients before and after treatment of clinical symptoms score, adverse reactions after treatment and disease recurrence rate.[Results] After treatment, the total effective rate was 96% in the observation group, which was significantly higher than that in the control group (P<0.05).In the case of patients with stomach pain, bloating, belching, poor stool, anorexia and other clinical symptoms similar to the case, the symptom scores in the observation group changed more after treatment, indicating better treatment(P<0.05).The observation group had 2 cases of nausea and vomiting, 1 case of flushing, the incidence of adverse reactions was 3%, which was significantly lower than that in the control group(P<0.05).At the follow-up of 3 months, only 3 patients had recurrence in the observation group, and the recurrence rate was 3%, which was significantly lower than that in the control group (P<0.05).[Conclusion] The combination of traditional Chinese and Western medicine treatment for atrophic gastritis has a high clinical value, effectiveness, safety and reliability, worthy of wide clinical application.