Abstract: [Objective] To summarize the clinical symptoms,endoscopic features,pathological phenomena and diagnosis and treatment of cervical heterotopic gastric mucosa in esophagus. [Methods]From January 2009 to July 2015,we retrospectively reviewed the clinical,endoscopic and pathologic features of 86 patients,as well as symptomatic treatment of acid suppression.[Results]The symptoms of pharyngeal soreness,poor swallowing or burning pain after sternum were the main symptoms.The rosette-orange red velvety-like plaques appeared in the endoscopy,which showed no difference with normal gastric mucosa,but with normal surrounding esophageal mucosa.For NBI(Narrow Band Imaging)observation,it was dark brown,showing more than flat or shallow depression.Dots or linear gland opening could be seen,and the boundary was clear.Pathological results for the main cells,parietal cells consisting mainly of gastric epithelial tissue,compared with the normal gastric mucosa structure,ductal atrophy performance.If symptoms occurred,the general symptomatic treatment of acid suppression could relieve clinical symptoms.[Conclusion]Cervical heterotopic gastric mucosa in esophagus can cause pharyngeal soreness,poor swallowing or burning sensation after sternum.Clinical symptoms can be caused by ulcers,bleeding and stenosis.Conventional endoscopy is easy to make misdiagnosis.Attention should be paid when performing gastroscopy.