A meta-analysis of chronic hepatitis B treated with telbivudine in combination with traditional Chinese medicine
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摘要: [目的]通过对慢性乙型肝炎患者的研究数据进行meta分析,探讨中西结合方法治疗慢性乙型肝炎的有效性与安全性,为中西结合方法的临床运用提供循证医学依据。[方法]研究国内外文献,筛选符合纳入标准的慢性乙型肝炎患者,纳入替比夫定结合中药与单使纯用替比夫定治疗慢性乙型肝炎比较的随机对照试验,按照Jadad评分标准,对比中西结合与单纯使用替比夫定治疗慢性乙型肝炎的疗效,并使用RevMan5.3对纳入的文献进行meta分析。[结果]共纳入14篇替比夫定结合中药与单纯使用替比夫定比较治疗慢性乙型肝炎的随机对照试验,共计1 281例慢性乙型肝炎患者,试验组644例,对照组637例,meta分析显示:中西结合治疗慢性乙型肝炎在HbeAg转阴率、HbeAg转换率、HBV DNA转阴率方面都高于单用西药替比夫定。[结论]替比夫定结合中药治疗慢性乙型病毒性肝炎的整体疗效优于单用替比夫定治疗。Abstract: [Objective]To investigate the efficiency and safety of combining traditional Chinese medication with western medication to treat chronic hepatitis B through meta analysis on data collected from patients with chronic hepatitis B and to provide evidence-based medical basis for the clinical practice of combining traditional Chinese medication with western medication.[Methods]Literature at home and abroad was studied.Patients with chronic hepatitis B who met the inclusion criterion since the data were selected.Then,a randomized controlled trial was conducted to analyze the treatment for chronic hepatitis B between two groups---Group One treated by telbivudine in combination with traditional Chinese medicine and Group Two treated solely by telbivudine.According to Jadad standards,discrepancy of efficiency of treatment for chronic hepatitis B was analyzed between traditional Chinese medication in combination with western medication and telbivudine.Meanwhile,selected documents were meta-analyzed using RevMan5.3.[Results]There are 14 randomized controlled trials about treatment for chronic hepatitis B using telbivudine in combination with traditional Chinese medicine and solely using telbivudine.Among 1 281 patients with chronic hepatitis B,there are 644 in experimental group and 637 in control group.Therefore,this methodology is not quite good.Meta analysis shows that treatment for chronic hepatitis B by traditional Chinese medication in combination with western medication is superior to that of solely using telbivudine in terms of HbeAg negative conversion rate,HbeAg conversion rate,and HBV DNA negative conversion rate.[Conclusion]The overall treatment for chronic hepatitis B using telbivudine in combination with traditional Chinese medicine is more efficient than that of solely using telbivudine.
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