Toxicity evaluation of Vinyl Alcohol Extract of Amorphophallus Konja on blood cells in mice with gastric cancer
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摘要: [目的]观察蛇六谷粗粉的乙烯醇提取物对小鼠血细胞的毒性作用。[方法]采用系统溶剂法,经初步提取得到蛇六谷乙烯醇部位,在正常小鼠皮下接种MFC胃癌肿块,连续喂食蛇六谷的乙烯醇提取物3周后,观察小鼠外周血中的血象,及小鼠脾重的前后变化。[结果]蛇六谷荷瘤组和荷瘤对照组相比,在观察期内小鼠体重无显著差异,小鼠血细胞的各项指标也无显著差变化,表明蛇六谷乙烯醇提取物对小鼠血细胞没有不良影响,并未产生毒性作用;而荷瘤对照组和无瘤对照组相比,小鼠白细胞明显增多,说明瘤块对小鼠产生了免疫应激反应。[结论]蛇六谷乙烯醇提取物作为抗胃癌药物,不会产生毒性作用,是安全的抗肿瘤药物。Abstract: [Objective] To observe the toxic effect of Vinyl Alcohol Extract of Amorphophallus Konja on blood cells in mice with gastric cancer.[Methods] Vinyl Alcohol Extract of Amorphophallus Konja was obtained by systematic solvent extraction.Normal mice were inoculated subcutaneously with MFC gastric tumor,fed with Vinyl Alcohol Extract of Amorphophallus Konja for 3 weeks,then peripheral hemogram and spleen weight changes were detected.[Results] In the observation period,between the tumor-bearing mice fed with and without Amorphophallus Konja,no significant differences in weight and hemogram parameters were demonstrated.It indicated that no adverse effect was induced by Vinyl Alcohol Extract of Amorphophallus Konja.Besides,leukocytes in tumor-bearing mice were significantly increased compared to those in tumor-free mice,indicating immune response was induced in mice by the gastric tumor.[Conclusion] As an effective anti-gastric cancer drug,Vinyl Alcohol Extract of Amorphophallus Konja extract has no toxic effect,which makes it also a safe therapy in clinic.
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Key words:
- Vinyl Alcohol Extract of Amorphophallus Konja extract /
- MFC mouse cells /
- blood cells /
- spleen /
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