奥曲肽治疗血吸虫肝硬化上消化道出血的临床评价

周纲; 邵丽芳

doi:10.3969/j.issn.1671-038X.2014.10.06

奥曲肽治疗血吸虫肝硬化上消化道出血的临床评价

周纲^1, ,,
邵丽芳²

- 1. 浙江省海宁市中医院外科, 浙江海宁 314400;
- 2. 浙江大学附属第一医院外科, 浙江杭州 310003
基金项目:
2010年浙江省医药卫生科学研究基金计划（No：2010KYA077）

详细信息

作者简介:
周纲,男,本科,主治医师,主要从事临床外科方面的研究

通讯作者: 周纲,E-mail:770938412@qq.com

中图分类号: R575.2

收稿日期: 2014-06-20

Clinical evaluation of octreotide on schistosoma cirrhotic patients with upper gastrointestinal bleeding

ZHOU Gang^1, ,,
SHAO Li-fang²

- 1. Surgical Department, Haining Hospital of Traditional Chinese Medicine, Haining 314400, China;
- 2. Surgical Department, the First Affiliated Hospital of Zhejiang University, Hangzhou 310000, China

More Information

Corresponding author: ZHOU Gang, E-mail: 770938412@qq.com

Received Date: 20 June 2014

摘要

摘要: [目的]探讨奥曲肽治疗血吸虫肝硬化上消化道出血的临床诊治特点和治疗效果。[方法]选择我院2011年4月~2014年1月收治的符合此次研究纳入标准的血吸虫肝硬化上消化道出血患者50例作为研究对象，按照随机对照原则，将患者随机分为对照组和实验组。实验组接受奥曲肽治疗，对照组进行垂体后叶素治疗，比较2组患者的临床疗效以及不良反应发生率等。[结果]实验组和对照组患者接受治疗后，实验组治疗总有效率为92.0%，对照组患者治疗总有效率为64.0%，2组比较差异有统计学意义（P<0.01）；实验组患者的平均止血时间、再出血率以及并发症发生率均低于对照组，2组比较差异有统计学意义（P<0.05）。[结论]奥曲肽在治疗血吸虫肝硬化上消化道出血方面较传统方法（垂体后叶素）临床效果显著，不良反应少，改善了患者的预后，提高了患者的生存质量，故该治疗方法值得在临床上进一步推广应用。
- 奥曲肽 /
- 血吸虫 /
- 肝硬化 /
- 上消化道出血
Abstract: [Objective] To investigate the clinical effects of octreotide in the treatment of schistosoma cirrhosis patients with gastrointestinal bleeding.[Methods] Schistosoma cirrhosis of the upper gastrointestinal bleeding patients who met the inclusion criteria were chosen in our hospital from April 2011 to January 2014.In accordance with the randomized principle, 50 patients were randomly divided into two groups, namely, control group(n=25) and experimental group(n=25).The patients in experimental group received the octreotide treatment, while the control group received the pituitrin.The curative effects and adverse effects of two groups were observed.[Results] After treatment, the curative effect rate in experimental group was higher than that in control group (92% vs 64%, P<0.003).The average hemostatic time, rebleeding rate, the incidence of complication in experimental group were lower than those in the control group(P<0.05).[Conclusion] Octreotide is effective and safe in treatment of schistosoma cirrhosis patients of the liver gastrointestinal bleeding.Ostreotide can increase the quality life of patients, deserving further clinic application.
- octreotide /
- schistosoma /
- cirrhosis /
- upper gastrointestinal bleeding

HTML全文

参考文献(12)

[1]	卢柏春, 钟华.奥曲肽和洛赛克合并治疗肝硬化并上消化道出血临床探讨[J].中国医药导报.2011, 6(18):90-91.
[2]	殷继东, 田德英, 黄巧新.抗纤合剂对血吸虫病肝纤维化的防治作用研究[J].中国中西医结合消化杂志, 2002, 10(6):348-351.
[3]	王沁, 朱红霞, 熊衍珉.血吸虫肝硬化上消化道出血应用奥曲肽治疗的临床分析[J].中国医药指南, 2013, 11(20):111-111.
[4]	严福建, 陈士淼, 曹雯勤, 等.奥曲肽与垂体后叶素联合治疗血吸虫性肝硬化上消化道出血[J].中国血吸虫病防治杂志, 2009, 21(3):224, 266.
[5]	蒋国法, 付宝娟.奥曲肽治疗肝硬化上消化道出血的临床观察[J].中国现代医生, 2011, 49(15):141-142.
[6]	邓玉花, 张瑞芳, 曹建国.肝硬化上消化道出血预后分析[J].河北医药, 2011, 33(9):1387-1387.
[7]	卢桂妲.奥曲肽联合普萘洛尔治疗肝硬化上消化道出血的临床研究[J].临床合理用药杂志, 2013, 6(17):66-67.
[8]	刘发巧.肝硬化上消化道出血的内科治疗方法及其效果[J].当代医学, 2012, 18(12):71-72.
[9]	单晓彬.奥曲肽治疗血吸虫性肝硬化上消化道出血[J].现代中西医结合杂志, 2005, 14(16):2088-2089.
[10]	王晋萍.奥曲肽治疗老年肝硬化患者上消化道出血的疗效分析[J].齐齐哈尔医学院学报, 2013, 34(10):1436-1436.
[11]	李旭声, 郑宗茂, 李国平.奥曲肽联合普奈洛尔治疗肝硬化上消化道出血的效果及对患者血流动力学的影响分析[J].当代医学, 2012, 18(19):71-72.
[12]	张为卿, 李方学, 何荣梅, 等.醋酸奥曲肽治疗肝硬化上消化道出血的疗效观察[J].临床合理用药杂志, 2012, 5(15):48-49.