氧化苦参碱对急性胰腺炎患者外周血TNF-α,IL-1和IL-6水平影响及临床疗效观察

徐丽琴

doi:10.3969/j.issn.1671-038X.2013.12.008

氧化苦参碱对急性胰腺炎患者外周血TNF-α,IL-1和IL-6水平影响及临床疗效观察

徐丽琴

- 临海市第二人民医院康复科, 浙江临海 317016

详细信息

作者简介:
徐丽琴,女,大学本科,从事消化内科专业

中图分类号: R284.1;R576

收稿日期: 2013-08-28

Effects of oxymatrine on TNF-α,IL-1and IL-6 levels of peripheral blood in patients with acute pancreatitis

XU Li-qin

- Physiatry Department, the Second People's Hospital of Linhai, Linhai 317016, China

Received Date: 28 August 2013

摘要

摘要: [目的]观察氧化苦参碱对急性胰腺炎(acute pancreastitis,AP)患者血清肿瘤坏死因子-α(TNF-α),白细胞介素-l(IL-1)和白细胞介素-6(IL-6)水平及临床疗效的影响。[方法]60例AP患者随机分为2组,对照组30例,给予止血、补液等常规处理;治疗组30例,在常规处理基础上加用氧化苦参碱治疗。观察2组治疗前、治疗第4天和治疗第7天血清TNF-α、IL-1和IL-6水平的变化。同时评价2组间白细胞恢复正常时间、血淀粉酶恢复时间、腹痛缓解时间。[结果]治疗第4天时2组TNF-α、IL-1和IL-6水平无明显差异(P>0.05),治疗第7天时,以上3项指标治疗组较对照组下降(P<0.05)。治疗组白细胞恢复正常时间、血淀粉酶恢复正常时间、腹痛缓解时间较对照组缩短1.13~2.58 d。[结论]氧化苦参碱能早期抑制AP患者炎症细胞因子TNF-α、IL-1和IL-6的水平,从而控制炎症的发展,尽早减轻AP的临床症状,改善患者的预后,值得在有条件的医院进一步推广应用。

关键词:氧化苦参碱; 胰腺炎,急性; 肿瘤坏死因子-α; 白细胞介素-1; 白细胞介素-6
中图分类号:R 284.1;R 576
- 氧化苦参碱 /
- 胰腺炎 /
- 急性 /
- 肿瘤坏死因子-α /
- 白细胞介素-1 /
- 白细胞介素-6
Abstract: [Objective][WT5BZ]To observe the effect of oxymatrine on serum TNF-α,IL-1 and IL-6 in patients with acute pancreatitis(AP)and the effects in treating patients with AP.[WT5HZ] [Methods][WT5BZ] Sixty cases of AP were randomly divided into 2 groups. Patients in control group(n=30)were treated with hemostasis,infusion and other conventional treatment,and patients in treatment group(n=30)were given oxymatrine additionally on the basis of routine treatment.Clinical efficacy was investigated in the two groups.The serum of patients before the therapy,on the 4th and 7th day of the therapy was taken to test TNF-α,IL-1 and IL-6 levels. The recovery time of leukocyte and hemodiastase as well as the relief time of bellyache were compared between the two groups .[WT5HZ][Results][WT5BZ] There was no significant difference in TNF-α,IL-1 and IL-6 between[HT]
- [Objective]To observe the effect of oxymatrine on serum TNF-α,IL-1 and IL-6 in patients with acute pancreatitis(AP)and the effects in treating patients with AP.[Methods] Sixty cases of AP were randomly divided into 2 groups. Patients in control group(n=30)were treated with hemostasis,infusion and other conventional treatment,and patients in treatment group(n=30)were given oxymatrine additionally on the basis of routine treatment.Clinical efficacy was investigated in the two groups.The serum of patients before the therapy,on the 4th and 7th day of the therapy was taken to test TNF-α,IL-1 and IL-6 levels. The recovery time of leukocyte and hemodiastase as well as the relief time of bellyache were compared between the two groups.[Results] There was no significant difference in TNF-α,IL-1 and IL-6 between the experiment group and control group on the 4th day(P>0.05),but statistically significant on the 7th day (P<0.05),which were decreased by 261.61ng/L,111.81ng/L and 21.66ng/L,respectively.The recovery time of leukocyte count and hemodiastase and the relief time of bellyache were shortened by 1.13~2.58 days compared to the control group.[Conclusion] Oxymatrine can decrease TNF-α,IL-1 and IL-6 levels of AP patients in early stage,thus can control the inflammation development,alleviate clinical symptoms,and improve the prognosis of the patients.It is worthy of further popularization and application in qualified hospitals. /

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