幽门螺杆菌感染与冠心病患者抗血小板治疗后上消化道出血的相关性研究

王启平

doi:10.3969/j.issn.1671-038X.2013.12.006

幽门螺杆菌感染与冠心病患者抗血小板治疗后上消化道出血的相关性研究

王启平

- 1. 沈阳军区总医院中医科, 国家中医药管理局消化病重点专科, 辽宁沈阳 110840;
- 2. 沈阳药科大学生命科学与生物制药学院临床药学专业研究生, 辽宁沈阳 110016

详细信息

作者简介:
王启平,男,医学学士,主治医师,从事心血管疾病临床内科工作

中图分类号: R541.4;R722.15

收稿日期: 2013-09-09

Relationship between Helicobacter pylori infection and upper gastrointestinal hemorrhage induced by anti-platelet therapy in patients with coronary heart disease

WANG Qi-ping

- 1. Traditional Chinese Medicine Department, the General Hospital of Shenyang;Military Command, Liaoning Shenyang 110840, China;
- 2. College of Life Science and Biological;Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

Received Date: 09 September 2013

摘要

摘要: [目的]探讨幽门螺杆菌(Hp)感染与冠心病(CHD)患者抗血小板治疗后发生上消化道出血的相关性,并观察根治Hp预防上消化道出血的效果。[方法]120例Hp阳性的CHD患者和30例Hp阴性患者(Hp阴性组)纳入研究,均行抗血小板治疗。Hp阳性患者随机分为2组,各60例,观察组给予Hp根除治疗,并在4周后观察治疗效果。所有患者随访1年,比较各组上消化道出血事件发生率的差异。[结果]对照组上消化道出血发生率为11.67%(7/60),高于观察组1.67%(1/60)和Hp阴性组的0(P<0.05)。观察组行Hp根除治疗后仍有5%(3/60)为阳性,其中1例发生上消化道出血,而95%(57/60)转为阴性,且无上消化道出血发生(P<0.05)。[结论]Hp感染可增加CHD患者抗血小板治疗时发生上消化道出血的风险,而根除Hp治疗能使出血风险降低。
- 冠心病 /
- 消化道出血 /
- 抗血小板治疗 /
- 幽门螺杆菌
Abstract: [Objective][WT5BZ]To investigate the correlation of Helicobacter pylori (Hp) infection with upper gastrointestinal hemorrhage after anti-platelet therapy in patients with coronary heart disease (CHD),and [HT]
- [Objective]To investigate the correlation of Helicobacter pylori (Hp) infection with upper gastrointestinal hemorrhage after anti-platelet therapy in patients with coronary heart disease (CHD),and the effect of eradicating Hp therapy for treating upper gastrointestinal hemorrhage.[Methods] One hundred and twenty cases of Hp positive CHD patients and 30 cases of Hp negative CHD patients who underwent anti-platelet therapy were enrolled in this study.The Hp positive patients were randomly divided into observation group and control group with 60 cases in each group.The observation group was given eradicating Hp therapy,and the therapeutic effects were observed after 4 weeks.All patients were followed up for 1 year,and the incidence of upper gastrointestinal hemorrhage events was observed and the difference among the groups was compared.[Results]The incidence of upper gastrointestinal hemorrhage in the control group was 11.67% (7/60),which was higher than 1.67% (1/60) in observation group and 0 in Hp negative group, respectively,and the difference had statistical significance (P<0.05).After 4 weeks of eradicating Hp therapy in observation group,there were 5% (3/60) patients remaining Hp positive,including 1 cases of upper gastrointestinal hemorrhage /
- and 95% (57/60) patients turned Hp negative,and no upper gastrointestinal hemorrhage occurred. The difference was statistically significant (P<0.05).[Conclusion]Hp infection can increase the risk of upper gastrointestinal hemorrhage in CHD patients with anti-platelet therapy,and eradicating Hp therapy can reduce this risk. /

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