Effect of Simo Decoction on functional dyspepsia with qi stagnancy of both liver and spleen and on Nitrie Oxide, Acetylcholinesterase, Cholecystokinin and Substance P in serum, the bottom of stomach, the gastric antrum and the duodenum
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摘要: [目的]观察四磨汤口服液对肝脾气滞证功能性消化不良（FD）患者血清、胃底、胃窦及十二指肠中NO、AchE、CCK、SP的影响。[方法]将符合纳入标准的FD患者60例，随机分为四磨汤+模拟多潘立酮治疗组30例和多潘立酮+模拟四磨汤对照组30例，治疗14 d，观察治疗前后患者血清、胃底、胃窦及十二指肠中NO、AchE、CCK、SP变化情况。[结果]经过14 d治疗后，四磨汤和多潘立酮均能降低FD患者血清、胃底、胃窦及十二指肠中NO、CCK的含量，提高FD患者血清、胃底、胃窦及十二指肠中AchE、SP的含量，从而调节FD患者胃肠运动，且四磨汤对FD患者胃肠激素的调节作用优于多潘立酮，2组相比差异有统计学意义（P<0.01或P<0.05）。[结论]四磨汤对FD患者血清、胃底、胃窦及十二指肠中NO、AchE、CCK、SP物质含量的调节，可能是其治疗肝脾气滞证FD的作用机制之一。Abstract: [Objective] To evaluate the effect of Simo Decoction on functional dyspepsia with qi stagnancy of both liver and spleen and on Nitrie Oxide, Acetylcholinesterase, Cholecystokinin and Substance P in serum, the bottom of stomach, the gastric antrum and the duodenum。[Methods] Sixty patients with functional dyspepsia were divided into treatment group and control group randomly according to the inclusive criteria, respectively given Simo Decoction and Domperidone tablets for 14 days. Then the levels of Nitrie Oxide, Acetylcholinesterase, Cholecystokinin and Substance P in serum, the bottom of stomach, the gastric antrum and the duodenum were observed before and after the treatment.[Results] After 14 days'treatment, both Simo Decoction and Domperidone reduced the contents of Nitrie Oxide and Cholecystokinin in FD patients'serum, the bottom of stomach, the gastric antrum and the duodenum, while the contents of Acetylcholinesterase and Substance P increased in these visceral organs, resulting in the gastrointestinal motility improvement. In addition, the regulation of Simo Decoction to gastrointestinal hormones was better than that of Domperidone, and the difference was significant.[Conclusion] The efficacy of Simo Decoction on functional dyspepsia with qi stagnancy of both liver and spleen can be achieved by adjusting the contents of Nitrie Oxide, Acetylcholinesterase, Cholecystokinin and Substance P in serum, the bottom of stomach, the gastric antrum and the duodenum.
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[1] MAHADEVA S, GOH K L.Epidemiology of functional dyspepsia:a global perspective[J].World Gastroentero, 2006, 12:2661-2666.
[2] DROSSMAN D A.The functional gastrointestinal disorders and the Rome process[J].Gastroenterology, 2006, 130:1377-1390.
[3] 郑筱萸.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社, 2002:134-134.
[4] TACK J, TALLEY N J, CAMILLEN M, et al.Functional gastroduodenal disorders[J].Gastroenterology, 2006, 130:1466-1479.
[5] KEOHANE J, QUIGLEY E M.Functional dyspepsia and nonerosive reflux disease:clinical interactions and their implications[J].Med Gen Med, 2007, 9:31-31.
[6] Van OUDENHOVE L, VANDENHERGHE J, GEEAMRTS B, et al.Relationship between anxiety and gastric ensorimotor function in functional dyspepsia[J].Psychosomatic Medicine, 2007, 69:455-463.
[7] THOMPSON W G.The road to Rome[J].Gastroenterology, 2006:1552-1556.
[8] 蔡东霞, 黄月红, 卢贤立, 等.一氧化氮在功能性消化不良发病机制中的作用[J].中国现代医学杂志, 2003, 13(1):81-81.
[9] 陈代陆, 余德文, 卢国良, 等.胆囊收缩素与功能性消化不良患者胃电活动及胃运动相关性的临床研究[J].中华消化杂志, 2003, 23(2):121-122.
[10] JUN J Y, CHOI S, YEUM C H, et al.Substance P induces inward current and regulates pacemaker currents through tachykinin NK1 receptor in cultured interstitial cells of Cajal of murine small intestine[J].Eur J Pharmacol, 2004, 495:35-42.
[11] 陈燕, 徐珊.功能性消化不良的现代研究与中医药治疗进展[J].浙江中医学院学报, 2005, 29(3):89-90.
[12] 赵芹, 林爱华, 黄裕新, 等.功能性消化不良与MTL, NO, SP和SS的关系[J].中国现代医学杂志, 2004, 14(11):136-137.
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