Efficacy and safety of omeprazole combined with carbazochrome sodium sulfonate in the treatment of upper gastrointestinal bleeding
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摘要: [目的]探讨奥美拉唑联合卡络磺钠治疗上消化道出血的疗效及安全性。[方法]选取2017年10月~2019年4月收治的214例上消化道出血患者,依据治疗方案分为实验组(n=110)和对照组(n=104),对照组给予奥美拉唑治疗,实验组在对照组的基础上给予卡络磺钠治疗。比较2组患者的治疗效果及不良反应发生率。[结果]实验组总有效率为94.55%(104/110),对照组为86.54%(90/104),组间比较差异有统计学意义(P<0.05);治疗后,2组患者血小板计数(PLT)、血红蛋白(Hb)、纤维蛋白原(FIB)水平与治疗前比较均差异有统计学意义(P<0.05),且实验组PLT、Hb水平升高幅度大于对照组,FIB水平降低幅度低于对照组,均差异有统计学意义(P<0.05);2组患者在治疗期间不良反应发生率比较差异无统计学意义(P>0.05)。[结论]奥美拉唑联合卡络磺钠治疗上消化道出血的疗效显著,可有效恢复PLT、Hb水平,对凝血功能影响较小且安全性好,值得临床推广应用。Abstract: [Objective]To investigate the efficacy and safety of omeprazole combined with carbazochrome sodium sulfonate in the treatment of upper gastrointestinal bleeding.[Methods]Two hundred and fourteen cases of patients with upper gastrointestinal bleeding admitted to the Department of Gastroenterology from October 2017 to April 2019 were enrolled.The patients were divided into the experimental group(n=110)and the control group(n=104)according to the treatment plan.Patients in the control group were treated with omeprazole,and patients in the test group were treated with carbazochrome sodium sulfonate on the basis of control group.The clinical efficacy and incidence of adverse reactions were compared between the two groups.[Results]The total effective rate of experimental group was 94.55%(104/110),and control group was 86.54%(90/104),there was statistically significant difference on the total effective rate between the two groups(P<0.05).There were statistically significant difference on the PLT,Hb,FIB levels of the two groups before and after treatment,and the increase on the PLT and Hb levels of experimental group were greater than that of control group,the decrease in FIB level was lower than that of control group.The incidence of adverse reactions during treatment were similar between the two groups(P>0.05).[Conclusion]Omeprazole combined with carbaryl sulfonate has significant curative effect on upper gastrointestinal bleeding,can effectively restore PLT and Hb levels,has little effect on coagulation function,and has good safety.It is worthy of clinical application.
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Key words:
- upper gastrointestinal bleeding /
- omeprazole /
- carbazochrome sodium sulfonate /
- efficacy /
- anemia /
- coagulation /
- safety
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