Influence of danshentone combined with mesalazine on high coagulation state in patients with active ulcerative colitis and clinical effect
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摘要: [目的]探讨丹参酮胶囊联合美沙拉嗪对活动期溃疡性结肠炎（UC）患者高凝状态的影响及其临床疗效。[方法]将84例UC患者随机分为观察组（42例）和对照组（42例），对照组给予口服美沙拉嗪肠溶片治疗，观察组给予口服丹参酮胶囊+美沙拉嗪肠溶片治疗，疗程均为8周；同时选取我院健康体检者40例作对照；检测2组患者治疗前及治疗后1、4及8周的凝血功能指标，如活化部分凝血酶原时间（APTT）、纤维蛋白原（FIB）、血小板计数（PLT）、D-二聚体（D-D）及C-反应蛋白（CRP），记录治疗前及治疗后的症状积分、肠镜下黏膜积分及结肠组织病理积分及临床疗效。[结果]与健康对照组比较，2组患者治疗前D-D、CRP、FIB、PLT均增高，APTT降低（P<0.05）；2组治疗后4、8周的D-D、CRP、PLT均降低（P<0.05），且观察组在治疗后4、8周低于对照组（P<0.05）；观察组治疗8周后的症状积分、肠镜下黏膜积分及结肠组织病理积分等均低于对照组（P<0.05）；观察组治疗后总有效率优于对照组（P<0.05）；多因素Logistic回归分析显示：D-D、CRP及肠镜下黏膜积分、广泛结肠病变是影响疗效的独立预测因素（P<0.05）。[结论]丹参酮胶囊联合美沙拉嗪治疗UC的临床疗效显著，在改善患者的临床症状方面优于单一美沙拉嗪，其机制与其抑制UC患者的炎症及改善患者的高凝状态有关。Abstract: [Objective] To explore the influence of danshentone combined with mesalazine on high coagulation state in patients with active ulcerative colitis(UC) and clinical effect.[Methods] Eighty-four patients with UC were randomly divided into observation group(n=42 cases) and control group(n=42 cases), control group were given oral treatment of mesalazine;the observation group was given treatment of danshentone combined with mesalazine, both groups were given a course of 8 weeks, meanwhile 40 cases of healthy people were chosen as contrast;coagulation function index such as activated partial prothrombin time(APTT), fibrinogen(FIB), platelet count(PLT), D-dimer(D-D), and C-reactive protein(CRP) of two groups were detected before treatment and 1, 4 and 8 weeks after treatment;score of symptoms, colonoscopy under mucosa and colon tissue pathological integral and clinical curative effect were recorded.[Results] Compared with healthy control group, D-D, CRP, FIB and PLT were higher before treatment(P<0.05), APTT were lower(P<0.05);D-D, CRP, PLT of two group were dcreased after treatment of 4, 8 weeks(P<0.05), D-D, CRP, PLT of observation group were lower than the control group(P<0.05);all index score of observation group were lower than the control group after treatment of 8 weeks(P<0.05);effective rate of observation group was higher than that of control group(95.2% vs 76.2%, chi square value=6.222, P=0.013).Multiariable Logistic regression analysis showed that D-D, CRP and score of colonoscopy under mucosa, extensive colon lesions were independent predictors of affect curative effect(P<0.05).[Conclusion] The clinical effect of danshentone combined with mesalazine is distinct, and improve the clinical symptoms by the mechanism of its inhibition of inflammation in patients with UC and improving high coagulation state of the patients.
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Key words:
- Danshentone /
- mesalazine /
- ulcerative colitis /
- high coagulation state
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