幽门螺杆菌感染儿童的药物治疗方案研究

陈丽贞

doi:10.3969/j.issn.1671-038X.2015.12.10

幽门螺杆菌感染儿童的药物治疗方案研究

陈丽贞

- 佛山市妇幼保健院药剂科, 广东佛山 528000

详细信息

作者简介:
陈丽贞,女,本科,主管药师,研究方向:儿科用药

中图分类号: R285

收稿日期: 2015-05-06

The research of drug treatment for children infected with Hp

CHEN Li-zhen

- Department of Pharmacy, Maternal and Child Health Hospital of Foshan City, Foshan 528000, China

Received Date: 06 May 2015

摘要

摘要: [目的]探讨以质子泵抑制剂(PPI)为基础的三联疗法联合布拉氏酵母菌对儿童幽门螺杆菌(Hp)的根除率以及不良反应的影响。[方法]选取本院自2012年6月~2014年12月期间收治的240例确诊为Hp感染的儿童患者为研究对象,随机分为对照组与治疗组,每组各120例。对照组采用三联疗法治疗,给予奥美拉唑、阿莫西林和克拉霉素治疗;治疗组在对照组基的础上加用布拉氏酵母菌。比较2组患者治疗后溃疡愈合的有效率,Hp根除率以及治疗过程中的不良反应发生情况。[结果]治疗组患者总有效率为90.8%,高于对照组75.8%,差异有统计学意义(P＜0.05);治疗组患者的Hp根除率为85.8%,高于对照组75.0%,差异有统计学意义(P＜0.05);治疗组患者的腹泻、腹痛、恶性呕吐等不良反应发生情况均低于对照组,差异有统计学意义(P＜0.05)。[结论]以PPI为基础的三联疗法联合布拉氏酵母菌治疗儿童Hp感染,不仅能提高溃疡愈合的有效率。Hp根除率,还能降低治疗使用抗生素带来的腹泻、腹痛、恶心等不良反应的发生率,提高患儿的依从性和耐受性,值得临床上推广。
- 三联疗法 /
- 幽门螺杆菌 /
- 布拉氏酵母菌 /
- 儿童
Abstract: [Objective] To investigate the effects of proton pump inhibitors(PPI)based triple therapy combined with Brad's yeast for children with Helicobacter pylori(Hp)eradication rates and side effects.[Methods] From June 2012 to December 2014, 240 cases who were diagnosed during the Hp infection in pediatric patients were randomly divided into control group and treatment group, with 120 cases in each group.The control group were treated with triple therapy,namely omeprazole,amoxicillin and clarithromycin treatment, while the treatment group were given Brad's yeast based on the above treatment The effective rate for ulcer healing, eradication rate of Hp as well as the adverse reactions during the treatment were observed and compared .[Results] The total effective rate was 90.8% in treatment group and 75.8% in control group. The difference was statistically significant(P＜0.05). The eradication rate was respectively 85.8% and 75.0% in the two groups,which was significantly different(P＜0.05). The incidence of adverse reactions, such as diarrhea,abdominal pain,vomiting and other malignant adverse events was lower in treatment group than control group(P＜0.05).[Conclusion] Triple therapy based on PPI combined with Brad's yeast treatment for children with Helicobacter pylori infection not only can improve ulcer healing efficiency and Hp eradication rate,but also reduce the incidence of antibiotic-related adverse reactions,including diarrhea,abdominal pain,the incidence of malignancies, ect. It can improve children's compliance and tolerance,which is worthy of wide clinical application.
- triple therapy /
- Helicobacter pylori /
- Saccharomyces boulardii /
- children

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参考文献(15)

[1]	SCHWIZER W,MENNE D,SCHOTZE K,et al.The effect of Helieobacter pylori infection and eradication in patients with gastro-oesophageal reflux disease:A parallel-group,double-blind,placebo-controlled muhicentre study[J].United European Gastroenterol J,2013,1:226-235.
[2]	CHUNG W C,JUNG S H,OH J H,et al.Dual-priming oligonucleotide-based multiplex PCR using tissue samples in rapid urease test in the detection of Helicobacter pylori infection[J].World J Gastroenterol,2014,20:6547-6553.
[3]	DOMIZIO P,LIU Y,BISSON L F,et al.Use of non Saccharomyces wine yeasts as novel sources of manno proteins in wine[J].Food Microbiol,2014,43:5-15.
[4]	徐志明,付慧琴.布拉氏酵母菌联合三联疗法对中老年幽门螺杆菌阳性消化性溃疡患者胃泌素和血浆胃动素的影响[J].中国中西医结合消化杂志,2014,22(11):668-671.
[5]	储波,蒋丽蓉,周莎,等.幽门螺杆菌菌株类型与儿童上消化道疾病的关系[J].中国当代儿科杂志,2007,9(3):201-204.
[6]	SCACCIANOCE G,ZULLO A,HASSAN C,et al.Triple therapies plus different probiotics for Helicobacter pylori eradicaton[J].Eur Rev Med Pharmacol Sci,2008,12:251-256.
[7]	朱哲宇,郭晓东,闫志辉,等.布拉氏酵母菌联合PPI三联疗法治疗幽门螺杆菌性消化性溃疡的临床疗效观察[J].现代生物医学进展袁2013,13(4):723-725,748.
[8]	郭姝,何利华,张建中,等.儿童幽门螺杆菌耐药及对大环内酯类抗生素的耐药基因分析[J].中华医学杂志,2014,94(8):563-566.
[9]	WIZLA-DERAMBURE N,MICHAUD L,ATEGBO S,et al.Familial and community environmental risk factors for Helicobacter pylori infection in children and adolescents[J].J Pediatr Gastroenterol Nutr,2001,33:58-63.
[10]	ODERDA G,SHCHERBAKOV P,BONTEMS P,et al.European Pediatric Task Force on Helicobacter pylori. Results from the pediatric European register for treatment of Helicobacter pylori(PERTH)[J].Helicobacter,2007,12:150-156.
[11]	赵红梅,欧阳红娟,段柏平,等.三联疗法联合布拉氏酵母菌治疗儿童幽门螺杆菌感染的临床研究[J].中国当代儿科杂志,2014,16(3):230-233.
[12]	赵丽然,夏庆,李玉梅,等.布拉氏酵母菌联合三联疗法治疗幽门螺杆菌消化性溃疡的临床疗效观察[J].湖南中医药大学学报,2013,33(4):18-19.
[13]	LESBROS-PANTOFLICKOVA D,CORTHRSY-THEULAZ I,BLUM A L.Helicobacter Pylori and probiotics[J].J Nutr,2007,37:812-813.
[14]	IAKOVENKO E P,GRIGOR’EV PLA,LAKOVENKO A V,et al.Effects of probiotic bififormon efficacy of Helicobacter priori infection treatment[J]J Ter Arkh,2006,78:21-26.
[15]	游国芹.布拉氏酵母菌联合三联疗法治疗52例幽门螺杆菌消化性溃疡的效果观察[J].中国现代药物应用,2014,8(3):148-149.