Exploring the biological connotations of "regulating the pivot with the pivot" in treating gastroesophageal reflux disease comorbid with depression based on the "microbiota-gut-brain axis"
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摘要: 胃食管反流病(gastroesophageal reflux disease，GERD)是一种常见的胃肠动力障碍性疾病，常与抑郁症共病，二者相互影响，形成恶性循环。菌群-肠-脑轴在GERD与抑郁症的共病中扮演了桥梁角色。谢胜教授基于对GERD及抑郁症发病机制的认识，提出“任督-脾胃枢机失和是GERD共病抑郁症的核心病机”，并据此制定了“以枢调枢”的治疗方法，即通过调和任督二脉的枢机功能来调节脾胃枢机。该疗法在临床上对GERD共病抑郁症的治疗效果显著，但其生物学机制尚待深入探索。菌群-肠-脑轴与人体“枢机”的生理学基础具有相似性。因此，本文从菌群-肠-脑轴的角度出发，探讨“以枢调枢”治疗GERD共病抑郁症的生物学机制，旨在为其“异病同治”策略提供新的理论依据和实践方法。Abstract: Gastroesophageal reflux disease(GERD) is a prevalent gastrointestinal motility disorder that often coexists with depression. The two conditions interact with each other, forming a vicious cycle. The microbiota-gut-brain axis plays a pivotal role in the comorbidity of GERD and depression. Professor XIE Sheng, based on his understanding of the pathogenesis of GERD and depression, proposed that "the disharmony of the Ren-Du-Spleen-Stomach pivot mechanism is the core pathogenesis of the comorbidity of GERD and depression". Accordingly, he formulated the "regulating the pivot with the pivot" therapeutic method, which involves modulating the pivot functions of the Ren and Du meridians to regulate the spleen and stomach pivot. This therapy has demonstrated significant clinical efficacy in treating the comorbidity of GERD and depression, but its biological mechanisms warrant further exploration. The microbiota-gut-brain axis shares similarities with the physiological basis of the human "pivot mechanism". Therefore, this paper delves into the biological mechanisms of the "regulating the pivot with the pivot" treatment for the comorbidity of GERD and depression from the perspective of the microbiota-gut-brain axis, aiming to provide new theoretical and practical approaches for the "treating different diseases with the same method" strategy.
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