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摘要: 肝性脑病是一种以代谢紊乱为基础的综合征，能够引起中枢神经系统功能失调。在肠-肝-脑轴功能异常的基础下，肝性脑病能够导致肠道菌群及其代谢产物发生变化、肠道通透性改变及细菌易位，引起全身和局部炎症，进一步影响肝脏及神经系统的功能。粪菌移植是一种新兴的特殊器官移植，是将粪便中正常功能菌群移植于患者肠道内，通过重建肠道菌群结构、调整体内的代谢过程和信号通路来帮助恢复重建肠道菌群的平衡。本文就粪菌移植在肝性脑病治疗中的作用机制以及研究进展进行综述。Abstract: Hepatic encephalopathy is a syndrome based on metabolic disorders, causing central nervous system dysfunction. Due to the abnormal function of the gut-liver-brain axis, hepatic encephalopathy can cause changes in the intestinal flora and its metabolites, intestinal permeability and microbiotal translocation leading to systemic and local inflammation, further affecting the function of the liver and nervous system. Fecal microbiota transplantation is an emerging special type of organ transplantation in which involves transplanting normal functional microbiota in feces into the intestinal tract of patients aimed at helping restore the balance of intestinal flora by reconstructing intestinal flora structure and adjusting metabolic processes and signaling pathways in vivo. This article reviews the mechanism and research progress of fecal microbiota transplantation in the treatment of hepatic encephalopathy.
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