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摘要: 肠黏膜炎又称肠道黏膜屏障损伤，是放化疗常见的剂量反应性毒性。以腹泻、疼痛、溃疡和营养不良为主要临床特征，严重者可出现水电解质紊乱，最终导致化疗中断，增加病死率。化疗相关肠黏膜损伤的发病机制多样，临床缺乏行之有效的治疗手段。近年来，越来越多的研究证实肠道菌群在化疗相关肠黏膜损伤的发生、发展中扮演着重要角色，但肠道菌群如何调控化疗相关肠黏膜损伤的具体机制尚不清楚。因此，本文从肠道菌群角度阐述其对化疗相关肠黏膜损伤的常见病理反应(炎症、氧化应激、肠黏膜屏障损伤)的调控作用，并以肠道菌群为载体，探讨潜在的治疗手段，为临床治疗与基础实验提供理论参考。Abstract: Intestinal mucosal inflammation, also known as intestinal mucosal barrier injury, is a common dose responsive toxicity of radiotherapy and chemotherapy. Diarrhea, pain, ulcers and malnutrition are the main clinical features, and water and electrolyte disorders occur in severe cases, which eventually lead to the interruption of chemotherapy and increase cancer mortality. The pathogenesis of chemotherapy related intestinal mucosal injury is diverse, and there is a lack of effective clinical treatment methods. In recent years, an increasing number of studies have confirmed that gut microbiota plays an important role in the occurrence and development of chemotherapy related intestinal mucosal injury. However, the specific mechanism of how intestinal flora regulates chemotherapy-related intestinal mucosal injury remains unclear. Therefore, from the perspective of intestinal flora, this paper describes its regulatory effect on common pathological reactions(inflammation, oxidative stress, intestinal mucosal barrier damage) associated with chemotherapy, and uses intestinal flora as a carrier to explore potential therapeutic means, providing important theoretical references for clinical treatment and basic experiments.
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