The clinical thinking of preventing and treating of "inflammation-cancer" transformation of colorectal adenoma by applying Professor CAI Gan's Yin-fire theory
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摘要: 蔡淦教授认为阴火与结直肠腺瘤的炎症机制相应，阴火稽留成积致结直肠腺瘤“炎-癌”转化；在治疗过程中，“补脾胃”须贯彻始终，“泻阴火”是防治“炎-癌”转化的关键；临证取健脾化痰、活血散结、清热解毒之法，扶正祛邪，标本同治。Abstract: This paper summarizes the academic experience of Professor Cai Gan in the prevention and treatment of "inflammation-cancer" transformation of colorectal adenoma by applying Li Dongyuan's Yin-fire theory. Professor Cai Gan believes that Yin-fire corresponds to the inflammatory mechanism of colorectal adenoma, and Yin-fire retention causes "inflammation-cancer transformation" of colorectal adenoma. In the treatment process, "tonifying spleen and stomach" should be carried out throughout, and "dredging Yin-fire" is the key to preventing and treating "inflammation-cancer transformation". In clinical practice, the methods of invigorating the spleen and Qi, activating blood circulation, and dispersing knots are adopted, supporting the positive and eliminating evil, and treating both symptoms and signs.
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[1] Han B, Zheng R, Zeng H, et al. Cancer incidence and mortality in China, 2022[J]. JNCC, 2024, 4(1): 47-53.
[2] 房静远, 时永全, 陈萦晅, 等. 中国结直肠癌预防共识意见(2016年, 上海)[J]. 胃肠病学, 2016, 21(11): 668-686. doi: 10.3969/j.issn.1008-7125.2016.11.006
[3] Holme Ø, Løberg M, Kalager M, et al. Long-term effectiveness of sigmoidoscopy screening on colorectal cancer incidence and mortality in women and men: arandomized trial[J]. Ann Intern Med, 2018, 168(11): 775-782. doi: 10.7326/M17-1441
[4] Choi WS, Han DS, Eun CS, et al. Three-year colonoscopy surveillance after polypectomy in Korea: a Korean Association for the Study of Intestinal Diseases (KASID) multicenter prospective study[J]. Intest Res, 2018, 16(1): 126-133. doi: 10.5217/ir.2018.16.1.126
[5] Cubiella J, Arias MD, Penin MC, et al. Immunohistochemical alterations in invasive adenocarcinoma in endoscopically resected adenoma and factors associated with risk of residual or recurrent disease[J]. Colorectal Dis, 2012, 14(9): e587-e594.
[6] Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow?[J]. Lancet, 2001, 357(9255): 539-545. doi: 10.1016/S0140-6736(00)04046-0
[7] Lukas M. Inflammatory bowel disease as a risk factor for colorectal cancer[J]. Dig Dis, 2010, 28(4-5): 619-624. doi: 10.1159/000320276
[8] Rothwell PM, Wilson M, Elwin CE, et al. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials[J]. Lancet, 2010, 376(9754): 1741-1750. doi: 10.1016/S0140-6736(10)61543-7
[9] Nadeem MS, Kumar V, Al-Abbasi FA, et al. Risk of colorectal cancer in inflammatory bowel diseases[J]. Semin Cancer Biol, 2020, 64: 51-60. doi: 10.1016/j.semcancer.2019.05.001
[10] Terzić J, Grivennikov S, Karin E, et al. Inflammation and colon cancer[J]. Gastroenterology, 2010, 138(6): 2101-2114. e5. doi: 10.1053/j.gastro.2010.01.058
[11] Neufert C, Heichler C, Brabletz T, et al. Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis[J]. Nat Protoc, 2021, 16(1): 61-85. doi: 10.1038/s41596-020-00412-1
[12] 殷坤, 权昕, 李杰, 等. 肿瘤相关性炎症在消化道肿瘤中的作用及机制研究进展[J]. 现代肿瘤医学, 2023, 31(19): 3684-3688. https://www.cnki.com.cn/Article/CJFDTOTAL-SXZL202319030.htm
[13] Li W, Deng X, Chen T. Exploring the modulatory effects of gut microbiota in anti-cancer therapy[J]. Front Oncol, 2021, 11: 644454. doi: 10.3389/fonc.2021.644454
[14] Disoma C, Zhou YZ, Li SN, et al. Wnt/β-catenin signaling in colorectal cancer: Is therapeutic targeting even possible?[J]. Biochimie, 2022, 195: 39-53. doi: 10.1016/j.biochi.2022.01.009
[15] Masrour-Roudsari J, Ebrahimpour S. Causal role of infectious agents in cancer: an overview[J]. Caspian J Intern Med, 2017, 8(3): 153-158.
[16] Khandia R, Munjal A. Interplay between inflammation and cancer[J]. Adv Protein Chem Struct Biol, 2020, 119: 199-245.
[17] Yu LX, Ling Y, Wang HY. Role of nonresolving inflammation in hepatocellular carcinoma development and progression[J]. NPJ Precis Oncol, 2018, 2: 6. doi: 10.1038/s41698-018-0048-z
[18] Yang ZH, Dang YQ, Ji G. Role of epigenetics in transformation of inflammation into colorectal cancer[J]. World J Gastroenterol, 2019, 25(23): 2863-2877. doi: 10.3748/wjg.v25.i23.2863
[19] Fatemi N, Tierling S, Es HA, et al. DNA methylation biomarkers in colorectal cancer: Clinical applications for precision medicine[J]. Int J Cancer, 2022, 151(12): 2068-2081. doi: 10.1002/ijc.34186
[20] Duizer C, de Zoete MR. The role of microbiota-derived metabolites in colorectal cancer[J]. Int J Mol Sci, 2023, 24(9): 8024. doi: 10.3390/ijms24098024
[21] 张伟健, 李海文, 梁艺钟, 等. 基于内镜下黏膜切除术的中西医治疗大肠息肉研究进展[J]. 中国中西医结合消化杂志, 2021, 29(8): 588-594. https://zxyxh.whuhzzs.com/article/doi/10.3969/j.issn.1671-038X.2021.08.13
[22] 康建媛, 黄彬, 张春虹. 中医药辨治结肠息肉的研究进展[J]. 广州中医药大学学报, 2020, 37(11): 2270-2273. https://www.cnki.com.cn/Article/CJFDTOTAL-REST202011045.htm
[23] 黄培英, 雷云霞, 刘慧. 结肠息肉中医药诊治进展[J]. 新疆中医药, 2017, 35(6): 123-125. https://www.cnki.com.cn/Article/CJFDTOTAL-XJZY201706043.htm
[24] 张正利, 赵会聪, 金佳丽. 蔡淦临证学术思想述要[J]. 中国中医药信息杂志, 2014, 21(3): 111-112. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY201403039.htm
[25] 蔡淦. 李东垣辨治内伤杂病的学术思想与遣方用药特色[J]. 上海中医药大学学报, 2013, 27(3): 4-6. https://www.cnki.com.cn/Article/CJFDTOTAL-SHZD201303004.htm
[26] (日)涩江抽斋. 灵枢讲义[M]. 北京: 学苑出版社, 2003: 802.
[27] 王颖, 李娟, 矫健鹏, 等. "阴火"发微[J]. 上海中医药大学学报, 2023, 37(3): 74-77. https://www.cnki.com.cn/Article/CJFDTOTAL-SHZD202303015.htm
[28] 步宏, 李一雷. 病理学[M]. 9版. 北京: 人民卫生出版社, 2018: 65-65.
[29] 李芳, 吴昊, 由凤鸣, 等. 从"代谢-免疫互作"论结肠炎癌转化"火不暖土"的病机[J]. 中医杂志, 2023, 64(20): 2086-2089, 2124. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ202320008.htm
[30] 彭丽蓉. 仙鹤草-黄连药对干预结直肠炎癌转化的作用与机制研究[D]. 南京: 南京中医药大学, 2022.
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