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摘要: 幽门螺杆菌(Helicobacter pylori，HP)感染在全球的流行率仍然很高，HP感染与多种疾病密切相关。抗生素治疗是HP感染的主要治疗方法，抗生素可能会导致细菌耐药、宿主胃肠道微生物群失衡等，临床上经常会有患者因各种原因而不宜接受抗生素治疗。因感染的HP对多种抗生素耐药，使得临床难以通过抗生素进行根除治疗，已成为抗生素耐药时代困扰患者和临床医生的难题。通过非抗生素替代疗法改善患者症状或者辅助抗生素治疗，是近年来备受关注的热点。本文针对免疫、益生菌、天然源性产品、中医药及其提取物、噬菌体、光疗等替代疗法在HP治疗中的应用及其可能机制进行综述。Abstract: The global prevalence of Helicobacter pylori(H.pylori) infection remains high. H.pylori infection is associated with many kinds of diseases. Antibiotic treatment is the main treatment therapy for H.pylori infection. Antibiotics may lead to bacterial resistance, imbalance of the host's gastrointestinal microbiota, etc. Some patients may not suitable for antibiotic treatment due to various reasons. It is difficult to successful eradicate through antibiotics for patients with multiple antibiotics resistant H.pylori infection, and this has become a challenge in the era of antibiotic resistance. Improving patient symptoms or adjuvant antibiotic therapy through non antibiotic alternative therapy has been a hot topic in recent years. This review will focus on alternative therapies such as immunity, probiotics, natural products, Chinese herbal medicine, bacteriophages, and phototherapy in the applications and possible mechanisms in the treatment of H.pylori infection.
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Key words:
- Helicobacter pylori /
- antibiotic resistance /
- alternative therapy /
- immunity /
- probiotics /
- plant therapy /
- bacteriophages /
- phototherapy
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