The role of hepatocellular derived exosomes in development of liver injuries in nonalcoholic fatty liver disease
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摘要: 外泌体是由多种类型的细胞分泌的一类膜状囊泡，在正常和病理状态下进行着细胞间通信的功能。越来越多的报道显示外泌体，尤其是肝细胞来源的外泌体在非酒精性脂肪性肝病(NAFLD)/非酒精性脂肪性肝炎(NASH)的发生中发挥重要作用。本文从肝细胞脂肪变性、凋亡和炎症、纤维化等肝损伤来阐释肝源性外泌体的影响机制，以期为NAFLD/NASH机制研究提供参考。Abstract: Exosomes are membranous vesicles secreted by a variety of cell types, and carry out the function of intercellular communication under normal and pathological conditions. More and more reports suggest that exosomes, especially hepatocellular derived exosomes, play an important role in the development of non-alcoholic steatohepatitis(NAFLD)/non-alcoholic steatohepatitis(NASH). In this review, we elucidate the mechanism of hepatogenic exosomes from the perspectives of liver injuries such as liver lipid metabolism, apoptosis, inflammation, and fibrosis, in order to provide reference for the study of NAFLD/NASH mechanism.
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