Advances in the regulation of LncRNA UCA1 on the pathogenesis of digestive system tumors
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摘要: 消化系统肿瘤因侵袭性强、预后差的特点，病死率呈现逐渐升高的趋势，目前已成为威胁人类健康的重要因素，但消化系统肿瘤发生、发展的机制目前仍不明确。近年来，随着RNA测序技术的发展，长链非编码RNA(long non-coding RNA，LncRNA)在癌症中的作用不断被发现。尿路上皮癌胚抗原1(urothelial carcinoma antigen 1，UCA1)在多种癌症中参与肿瘤细胞的增殖、侵袭、迁移、耐药性，本文就UCA1在胃癌、食管癌、结直肠癌、肝细胞癌、胰腺癌中的作用及化疗耐药的分子调控机制、诊断和预后价值等方面的研究进展进行综述。Abstract: Due to the digestive system tumors strong invasiveness and poor prognosis, the mortality rate of digestive system tumors show a gradually increasing trend, which has become an important factor threatening human health at present. However, the mechanism of the occurrence and development of digestive system tumors is still unclear. In recent years, with the development of RNA sequencing technology, the role of long non-coding RNA(LncRNA) in cancer has been continuously discovered. Urothelial carcinoembryonic antigen 1(UCA1) in a variety of cancer participate in tumor cell proliferation, invasion, migration, drug resistance. In this review, the role of UCA1 in gastric cancer, esophageal cancer, colorectal cancer, hepatocellular carcinoma, pancreatic cancer, molecular regulation mechanism of chemotherapy resistance, diagnostic and prognostic value of UCA1 were reviewed.
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