Investigation on the feasibility of the treatment of gastroesophageal reflux disease by Back-Shu finger acupressure therapy based on the autophagy mediated by the circadian rhythm disorder of esophageal ICC
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摘要: 昼夜节律与细胞自噬均为当前的研究热点，在健康与疾病中均发挥着关键作用，但在胃食管反流病(gastroesophageal reflux disease，GERD)领域的研究甚少。GERD存在食管昼夜节律紊乱及Cajal间质细胞(interstitial cells of Cajal，ICC)自噬，而细胞自噬受食管昼夜节律直接调控。因此推测食管昼夜节律紊乱可导致ICC自噬而引发GERD。基于营卫节律是昼夜节律的基础，营卫节律受任督二脉经气运行节律调节；背俞指针疗法可显著改善GERD大鼠食管病理改变，拮抗食管ICC自噬，改善任督二脉经气交会，是治疗GERD的有效疗法。因此，基于课题组提出的“以俞调枢”“以枢调律”理论，本文探讨背俞指针疗法通过调控食管昼夜节律介导ICC自噬达到治疗GERD之目的的可行性，进一步为该疗法治疗GERD等胃肠动力障碍性疾病获效提供理论依据。Abstract: Circadian rhythm and autophagy have been the focus of current research, which play a key role in health and disease. However, there is few research in the field of gastroesophageal reflux disease(GERD). GERD has esophageal circadian rhythm disorder, and its pathogenesis is closely related to autophagy of esophageal interstitial cells of Cajal(ICC). Esophageal circadian rhythm directly regulates autophagy. Therefore, it is speculated that esophageal circadian rhythm disorder can lead to ICC autophagy and lead to GERD. Yingwei rhythm is the basis of circadian rhythm, and Yingwei rhythm is regulated by the rhythm of Qi of Ren and Du meridian. Back-Shu finger acupressure therapy can significantly improve the pathological changes of esophagus in GERD rats, antagonize the autophagy of esophageal ICC, and improve the qi intersection between Ren and Du meridian, which is an effective treatment for GERD. Therefore, based on the "Shu adjusted pivot-pivot adjusted pivot-pivot adjusted rhythm" theory, this paper investigates on the feasibility of the treatment of GERD by Back-Shu finger acupressure therapy based on the autophagy mediated by the circadian rhythm disorder of esophageal ICC, providing a theoretical basis for the treatment of gastrointestinal motility disorders such as GERD.
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