结直肠息肉患者机体总氧化和抗氧化状态的评估及意义

梁海清; 邹朝平; 卢美丽; 李一然

doi:10.3969/j.issn.1671-038X.2021.12.003

结直肠息肉患者机体总氧化和抗氧化状态的评估及意义

- 1. 德州市人民医院内二科(山东德州, 253014);
- 2. 德州市人民医院检验科

详细信息

通讯作者: 梁海清,E-mail:lianghq678@sina.com

中图分类号: R574.62

收稿日期: 2021-09-17

Evaluation of the total oxidation and antioxidant status in colorectal polyps patients

- 1. Second Department of Internal Medicine, Dezhou People's Hospital, Dezhou, 253014, China;
- 2. Department of Clinical Laboratory, Dezhou People's Hospital

More Information

Corresponding author: LIANG Haiqing, E-mail: lianghq678@sina.com

Received Date: 17 September 2021

摘要

摘要: 目的：通过测定结直肠息肉患者血清中总氧化状态及总抗氧化状态水平，分析结直肠息肉患者机体氧化应激状态，并探讨其在结直肠息肉发病机制及临床防治中的意义。方法：收集64例结直肠息肉患者和18例健康对照人群的空腹血清样本，采用ELISA方法检测氧化应激参数，包括人总氧化状态（TOS）与人抗氧化剂总状态（TAS）水平，并计算氧化应激指数（OSI）。结果：与健康对照组比较，结直肠息肉组血清TOS[（26.59±5.58） U/mL vs （19.05±3.29） U/mL]、OSI[（1.09±0.36） vs （0.57±0.14）]水平显著升高（P均<0.001），TAS[（25.53±5.54） U/mL vs （33.85±3.90） U/mL]水平显著降低（P<0.001）；[JP2]氧化应激参数随息肉大小变化，息肉直径 ≥ 10 mm组较直径<10 mm组TOS[（27.87±5.39） U/mL vs （24.17±5.21） U/mL]、OSI[（1.19±[JP]0.36） vs （0.93±0.29）]水平显著升高（P均<0.05），TAS水平大息肉组[（24.74±5.70） U/mL]低于小息肉组[（27.02±5.00） U/mL]，差异无统计学意义（P>0.05）；不同息肉个数患者间TOS、TAS、OSI水平差异无统计学意义（P>0.05）。结论：结直肠息肉患者体内总氧化能力激活，总抗氧化能力减弱，过高的氧化应激水平可能参与了结直肠息肉的发生发展。
- 结直肠息肉 /
- 氧化应激 /
- 总氧化状态 /
- 总抗氧化状态 /
- 氧化应激指数
Abstract: Objective: Analyzing the oxidative stress status by detecting the level of the total oxidation state and total antioxidant state in the serum of patients who suffer from colorectal polyps, further exploring the potential pathogenesis of colorectal polyps. Methods: Collecting the fasting serum from 64 patients with colorectal polyps and 18 healthy controls. Then the level of Oxidative stress parameters were detected by ELISA, including total human oxidation status(TOS) and total human antioxidant status(TAS), further, calculating the oxidative stress index(OSI). Results: The level of TOS[(26.59±5.58) U/mL]and OSI(1.09±0.36) in the colorectal polyp group was increased significantly comparing with the control group[TOS(19.05±3.29) U/mL、OSI(0.57±0.14)](P<0.001). Meanwhile, the level of the TAS[(25.53±5.54) U/mL]in the colorectal polyp group was decreasing significantly comparing with the control group[(33.85±3.90) U/mL](P<0.001); the level of TOS[(27.87±5.39) U/mL]and OSI(1.19±0.36) in the diameter ≥ 10 mm group was increased significantly comparing with diameter <10 mm group[TOS(24.17±5.21) U/mL,OSI(0.93±0.29)](P<0.05).However, the level of the TAS was no significant[(24.74±5.70) U/mL vs (27.02±5.00) U/mL](P>0.05); there was no significant difference about the level of TOS, TAS and OSI among patients with different number of polyps(P>0.05). Conclusion: In colorectal polyps patients, oxidative stress is activated and the total antioxidant capacity is weakened. It is possible the high level of oxidative stress has certain correlation with development of colorectal polyps.
- colorectal polyps /
- oxidative stress /
- total oxidation state /
- total antioxidant status /
- oxidative stress index

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