Observation on the curative effect of Liujunzi Modified Decoction on chronic atrophic gastritis with spleen and stomach weakness with dysplasia
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摘要: 目的:观察六君子加减方治疗脾胃虚弱型慢性萎缩性胃炎伴轻、中度异型增生的临床疗效。方法:前瞻性纳入2017年12月—2019年12月于北京大学第一医院中西医结合科门诊就诊的脾胃虚弱型慢性萎缩性胃炎伴轻、中度异型增生者,予以六君子加减方治疗6个月。评价患者治疗前后胃黏膜病理积分、临床症状和安全性。结果:共纳入32例患者,脱落2例,30例完成胃镜复查及相关症状调查。治疗后胃黏膜异型增生积分较治疗前明显降低(P<0.05);26例患者轻度异型增生者复查未见异型增生,其余1例情况稳定、1例进展为中度异型增生,2例中度异型增生患者复查均未见异型增生。治疗第3个月及第6个月胃脘胀满、胃脘疼痛、口淡、乏力、气短、胸闷、嗳气反酸及口苦口干积分及症状积分均较治疗前明显降低(P<0.05),治疗第3个月及第6个月症状改善总有效率分别为75.00%和86.67%。结论:六君子加减方可有效改善脾胃虚弱型慢性萎缩性胃炎伴轻、中度异型增生患者胃黏膜病变,缓解临床症状,安全性高,具有重要的研究价值。Abstract: Objective: To observe the clinical effect of Liujunzi Modified Decoction in treating chronic atrophic gastritis with spleen and stomach weakness with mild to moderate dysplasia.Methods: Prospectively enrolled patients with spleen and stomach weakness with mild to moderate dysplasia in the Department of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital from December 2017 to December 2019, and were treated with Liujunzi Modified Formula for 6 months. To evaluate the pathological score, clinical symptoms and safety of the gastric mucosa before and after treatment.Results: A total of 32 patients were enrolled, 2 of them fell off, and 30 patients completed the gastroscopy review and related symptom investigation. After treatment, the score of gastric mucosal dysplasia was significantly lower than before treatment(P<0.05); Twenty-six patients with mild dysplasia did not show dysplasia after reexamination, the remaining 1 case was stable, 1 case progressed to moderate dysplasia, 2 patients with high-degree dysplasia found dysplasia in reexamination. Stomach fullness, gastric pain, light mouth, fatigue, shortness of breath, chest tightness, belching, acid reflux, dry mouth and dry mouth scores and symptom scores were significantly lower than before treatment in the third and sixth months of treatment(P<0.05), The total effective rate of symptom improvement in the third and sixth months of treatment was 75.00% and 86.67%, respectively.Conclusion: Liujunzi Modified Decoction can effectively improve gastric mucosal lesions in patients with chronic atrophic gastritis with spleen and stomach weakness with mild to moderate dysplasia, relieve clinical symptoms, and have high safety. It has important research value.
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