健脾扶正方对接受新辅助化疗胃癌患者近期疗效和免疫功能的影响

文政伟; 万春霞; 何均辉; 陶红发

doi:10.3969/j.issn.1671-038X.2021.01.03

健脾扶正方对接受新辅助化疗胃癌患者近期疗效和免疫功能的影响

- 1 深圳市宝安区松岗人民医院消化科(广东深圳, 518000);
- 2 深圳市宝安区松岗人民医院普通外科

详细信息

通讯作者: 文政伟,E-mail:ddwwsx809@163.com

中图分类号: R473.73

收稿日期: 2020-09-20

Effect of Jianpi Fuzheng prescription on short-term efficacy and immune function of gastric cancer patients receiving neoadjuvant chemotherapy

- 1 Department of Gastroenterology, Songgang People's Hospital, Bao'an District of Shenzhen, Shenzhen, 518000, China;
- 2 Department of General Surgery, Songgang People's Hospital, Bao'an District of Shenzhen

More Information

Corresponding author: WEN Zhengwei, E-mail: ddwwsx809@163.com

Received Date: 20 September 2020

摘要

摘要: 目的:探讨健脾扶正方应用于胃癌患者新辅助化疗的疗效。方法:将90例进展期胃癌患者按照随机数字表法分为2个组,每组45例。2组均接受新辅助化疗和胃癌根治术,中药组在新辅助化疗期间应用中药健脾扶正方,对照组仅接受新辅助化疗。比较2组近期疗效和免疫功能。结果:化疗后中药组客观有效率、疾病控制率、R0切除率均高于对照组(P<0.05),化疗后、术后第7天中药组CD3⁺、CD4⁺、CD4⁺/CD8⁺值高于对照组(P<0.05);化疗后中药组血清癌胚抗原、糖类抗原724、基质金属蛋白酶-9、血管内皮生长因子水平均低于对照组(P<0.05);中药组白细胞减少、血小板减少、贫血、恶心呕吐、食欲减退、全身乏力、脱发、口腔黏膜炎发生率低于对照组,均差异有统计学意义(P<0.05)。结论:健脾扶正方可调节细胞免疫功能,提高近期疗效,下调肿瘤标志物水平,减少不良反应发生,应用于进展期胃癌的新辅助化疗效果显著,值得临床借鉴。
- 胃癌 /
- 新辅助化疗 /
- 健脾扶正方
Abstract: Objective: To investigate the efficacy of Jianpi Fuzheng prescription in neoadjuvant chemotherapy for gastric cancer patients.Methods: A total of 90 patients with advanced gastric cancer were divided into 2 groups according to the random number table method, with 45 patients in each group. Both groups received adjuvant chemotherapy and radical gastrectomy, and the Chinese medicine group used Chinese medicine Jianpi Fuzheng prescription during neoadjuvant chemotherapy. The short-term efficacy, R0 resection rate and incidence of toxic and side effects were compared between the two groups. The contents of CD3⁺,CD4⁺,IgA,IgM,IgG and CD4⁺/CD8⁺ in peripheral blood of the two groups were compared before chemotherapy, after chemotherapy, and 7 days after surgery. Serum carcino-embryonic antigen(CEA), carbohydrate antigen(CA) 724, matrix metalloproteinase(MMP)-9 and vascular endothelial growth factor(VEGF) levels were compared before and after chemotherapy.Results: After chemotherapy, the objective effective rate, disease control rate and R0 resection rate in the Chinese medicine group were all higher than those in the control group(P<0.05). The values of CD3⁺,CD4⁺and CD4⁺/CD8⁺ in the Chinese medicine group were higher than those in the control group(P<0.05) 7 days after surgery. After chemotherapy, serum CEA,CA724,MMP-9 and VEGF levels in the Chinese medicine group were all lower than those in the control group(P<0.05), and the incidence of leukopenia, thrombocytopenia, anemia, nausea and vomiting, appetite loss, malaise, alopecia and oral mucositis were lower than those in the control group(P<0.05), with statistically significant differences.Conclusion: Jianpi Fuzheng prescription can regulate cellular immune function, improve the short-term efficacy, down-regulate the level of tumor markers, reduce the toxic and side effects, and it's effective in neoadjuvant chemotherapy for advanced gastric cancer, worthy of clinical reference.
- gastric cancer /
- neoadjuvant chemotherapy /
- Jianpi Fuzheng prescription

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