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摘要: [目的]评价血清脂联素对西宁地区胃癌患者的诊断价值研究。[方法]选择2016年1月~2018年6月在我院就诊的胃癌患者60例作为研究对象,再选择同期就诊的胃良性疾病患者100例和健康体检人群110例作为对照组,比较3组血清脂联素、CEA、CA19-9和CA72-4水平,再根据受检者是否合并Hp感染进行分组比较,使用ROC曲线评价各指标对胃癌的诊断效能。[结果]胃癌组脂联素水平低于健康对照、胃良性疾病组(P＜0.01),CEA、CA19-9、CA72-4水平高于健康对照组、胃良性疾病组(P＜0.01);幽门螺杆菌(Hp)感染者胃癌组脂联素低于健康对照、胃良性疾病组(P＜0.01),胃癌组血清CEA,CA19-9,CA72-4水平高于健康对照组、胃良性疾病组(P＜0.01);未感染Hp者胃癌组脂联素水平低于健康对照组、胃良性疾病组(P＜0.01),胃良性疾病组CEA、CA19-9、CA72-4水平高于健康对照组(P＜0.01),胃癌组CEA、CA72-4水平高于胃良性疾病组(P＜0.01),胃癌组CA72-4高于健康对照组(P＜0.01);Hp感染胃癌患者CEA、CA19-9、CA72-4水平高于未感染组(P＜0.01),而血清脂联素水平差异无统计学意义;单项检测时脂联素的ROC曲线下面积(AUC)最高,后续依次为CA72-4、CEA、CA19-9,联合检测时AUC高于单项检测。[结论]脂联素诊断效能高于CEA、CA19-9、CA72-4,而且Hp感染不影响脂联素的诊断效能,4项指标联合检测可大大提高对胃癌早期诊断的准确率。Abstract: [Objective] To evaluate the diagnostic value of serum adiponectin in patients with gastric cancer in Xining area.[Methods]From January 2016 to June 2018,60 patients with gastric cancer who were treated in our hospital were selected as the study subjects.Then 100 patients with benign gastric diseases and 110 healthy people were selected as control group.The serum levels of adiponectin,CEA,CA19-9 and CA72-4 were compared among three groups.Then,according to whether the patients were infected with Helicobacter pylori,grouping comparison was made.ROC curve was used to evaluate diagnostic efficacy of serum adiponectin,CEA,CA19-9 and CA72-4 for gastric cancer.[Results]The level of adiponectin in gastric cancer group was lower than that in healthy control group and benign gastric disease group(P＜0.01),while the levels of CEA,CA19-9 and CA72-4 were higher than those in healthy control group and benign gastric disease group(P＜0.01).The level of adiponectin in gastric cancer group with Helicobacter pylori infection was lower than that in healthy control group and benign gastric disease group(P＜0.01).Serum CEA,CA19-9,CA72-4 levels in cancer group were higher than those in healthy control group and benign gastric disease group(P＜0.01).The level of adiponectin in gastric cancer group with Helicobacter pylori uninfected were lower than those in healthy control group and benign gastric disease group(Z=6.261,7.734,P＜0.01).The levels of CEA,CA19-9 and CA72-4 levels in benign gastric disease group were higher than those in healthy control group(P＜0.01).The levels of CEA and CA72-4 in gastric cancer group were higher than those in benign gastric disease group(P＜0.01),and CA72-4 in gastric cancer group were higher than those in healthy control group(P＜0.01).The levels of CEA,CA19-9 and CA72-4 in gastric cancer patients infected with Helicobacter pylori were higher than those in uninfected group(P＜0.01),but there was no significant difference in serum adiponectin level;the area under ROC curve of adiponectin was the highest in single test,followed by CA72-4,CEA,CA19-9,and AUC was higher in combined test than in single test.[Conclusion]The diagnostic efficiency of adiponectin is higher than that of CEA,CA19-9 and CA72-4,and Helicobacter pylori infection does not affect the diagnostic efficiency of adiponectin.The combined detection of four indicators can greatly improve the accuracy of early diagnosis of gastric cancer.
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Key words:
- gastric cancer /
- biomarkers /
- adiponectin /
- diagnostic efficacy
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