应用Logistic回归和ROC曲线评价PCT、NLR对肝硬化合并细菌感染的诊断价值

邢芳芳; 赵春明; 吴峰; 邢颖; 薛姗; 周建红; 周海英; 廖腾俊

doi:10.3969/j.issn.1671-038X.2018.07.06

应用Logistic回归和ROC曲线评价PCT、NLR对肝硬化合并细菌感染的诊断价值

- 1. 中国人民解放军第98医院消化内科, 浙江湖州 313000;
- 2. 中国人民解放军第98医院心内科, 浙江湖州 313000
基金项目:
国家自然科学基金资助项目（No：81400207）

详细信息

作者简介:
邢芳芳,女,本科,主治医师,研究方向:消化内科常见疾病诊治

通讯作者: 邢芳芳,E-mail:doctor_xff@163.com

中图分类号: R575.2

收稿日期: 2018-03-18

The diagnostic value of serum PCT and NLR with logistic regression and ROC curve in cirrhosis with bacterial infection

- 1. Department of Gastroenterology, The 98th Hospital of the Chinese People's Liberation Army, Zhejiang, Huzhou 313000, China;
- 2. Department of Cardiology, The 98th Hospital of the Chinese People's Liberation Army, Zhejiang, Huzhou 313000, China

More Information

Corresponding author: XING Fang-fang, E-mail: doctor_xff@163.com

Received Date: 18 March 2018

摘要

摘要: [目的]采用logistic回归和ROC曲线评价PCT、中性粒细胞与淋巴细胞比值（NLR）在肝硬化合并细菌感染中的诊断价值。[方法]回顾性收集32例肝硬化合并细菌感染患者，同期选取肝硬化患者未合并感染者64例，分别提取2组患者血清PCT、中性粒细胞及淋巴细胞测定结果。[结果]2组患者性别、年龄分布无差异（P>0.05），肝硬化合并细菌感染组患者血清PCT、NLR水平高于非感染组（P<0.05）。血清PCT诊断肝硬化合并细菌感染ROC曲线下面积为0.848，诊断最佳临界值为0.69 ng/ml，灵敏度为87.50%，特异度为70.31%。NLR诊断肝硬化合并细菌感染ROC曲线下面积为0.689，诊断最佳临界值为12.5，灵敏度为68.75%，特异度为62.50%。PCT联合NLR诊断肝硬化合并细菌感染ROC曲线下面积为0.857，诊断灵敏度为81.25%，特异度为80.20%。Z检验结果提示，PCT、NLR联合试验诊断ROC曲线下面积大于NLR （P<0.05），而与PCT检测ROC曲线下面积大小无差异（P>0.05），血清PCT诊断肝硬化合并细菌感染ROC曲线下面积大于NLR （P<0.05）。[结论]血清PCT在肝硬化合并细菌感染中诊断价值较高，尚未发现PCT、NLR联合试验能够改良诊断效能。
- 肝硬化 /
- 感染 /
- 降钙素原 /
- 中性粒细胞/淋巴细胞比值
Abstract: [Objective] To analysis the diagnostic value of serum PCT and NLR with logistic regression and ROC curve in cirrhosis with bacterial infection.[Methods] A total of 32 cirrhosis patients with bacterial infection and 64 cirrhosis patients without infection were retrospectively collected from January 2015 to December 2017, and serum PCT and NLR were recorded in both groups.[Results] The gender and age distribution of the two groups were well balanced(P>0.05).The levels of serum PCT and NLR in patients with cirrhosis combing with bacterial infection were higher than those in non-infected group(P<0.05).The area under the ROC curve of serum PCT in diagnosing cirrhosis with bacterial infection was 0.848, the best diagnostic threshold was 0.69 ng/ml, the sensitivity was 87.50% and the specificity was 70.31%.The area under the ROC curve of NLR in diagnosing cirrhosis with bacterial infection was 0.689, the best diagnostic threshold was 12.5, the sensitivity was 68.75% and the specificity was 62.50%.The area under the ROC curve of PCT combined with NLR in diagnosing cirrhosis with bacterial infection was 0.857, the diagnostic sensitivity was 81.25% and the specificity was 80.20%.The results of Z test showed that the areas under the ROC curves of PCT and NLR combined tests were larger than NLR(P<0.05), but there was no significant difference in the areas under the ROC curve between PCT and joint test(P>0.05), and there was significant difference in the areas under the ROC curve between PCT and NLR.[Conclusion] The diagnostic value of Serum PCT in cirrhosis with bacterial infection was high, and there was no evidence that combined trials can improve their diagnostic performance.
- cirrhosis /
- infection /
- procalcitonin /
- Neutrophil-lymphocyte ratio

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