Clinical observation of plasma exchange combined with plasma adsorption in the treatment of chronic hepatitis with jaundice
-
摘要: [目的]探究血浆置换联合血浆吸附治疗慢性肝炎黄疸的临床效果。[方法]选取我院收治的慢性肝炎患者100例, 随机分为观察组和对照组, 每组各50例。对照组患者给予综合治疗并加强护理, 对照组患者在综合治疗的基础上给予血浆置换联合血浆吸附治疗。[结果]对比2组患者的肝功能指标、临床效果以及不良反应的发生率。得出结果在总有效率上, 观察组达到86%, 对照组达到62%, 能够发现观察组比对照组明显要高 (P＜0.05)。在治疗前, 2组患者白蛋白 (ALB)、总胆固醇、天门冬氨酸氨基转移酶 (AST)、丙氨酸氨基转移酶 (ALT) 这4项指标差异均无统计学意义 (P＞0.05)。治疗后, 观察组的总胆固醇指标与ALB比对照组明显要高 (P＜0.05)。术后2组患者均无严重的不良反应, 治疗后明显好转, 组间比较, 差异无统计学意义 (P＞0.05)。[结论]血浆置换联合血浆吸附治疗慢性肝炎黄疸的临床效果显著, 值得推广并使用。Abstract: [Objective] To explore the plasma adsorption plasmapheresis clinical effect for the treatment of chronic hepatitis with jaundice.[Methods] 100 cases of patients with chronic hepatitis were selected from our hospital randomly, and equally divided into observation group and control group.The control group patients were given comprehensive treatment and strengthening nursing, the observation group patients were treated basic comprehensive therapy combined plasma adsorption plasmapheresis.We compare the clinical curative effect, liver function index, the incidence of adverse reactions between these two groups.[Results] The total effective rate of observation group patients was significantly higher than the control group, 62.00%vs.86.00% (P＜0.05).Before the treatment, there was no significantly difference between two groups in albumin (propagated), total cholesterol, aspartate amino transferase (AST), alanine aminotransferase (ALT) (P＞0.05).After treatment, the observation group of patients with propagated and total cholesterol levels were significantly higher than the control group, AST, ALT indexes were significantly lower than the control group (P＜0.05).Furtherly, we found that there was no significantly difference between these two groups in serious adverse reactions (P＞0.05).[Conclusion] Plasma exchange combined plasma adsorption could be used in the treatment of chronic hepatitis with jaundice.
-
Key words:
- plasma exchange /
- plasma adsorption /
- chronic hepatitis jaundice
-
-
[1] 甘玉萍.人工肝 (血浆置换+胆红素吸附) 联合治疗重型肝炎、肝功能衰竭的临床疗效[J].中国医药指南, 2016, 14 (12):141-143.
[2] 蔡峻岭, 王合群, 魏巧云, 等.血液灌注和血浆置换联合熊去氧胆酸治疗慢性重型肝炎[J].临床医学, 2014, 34 (7):63-65.
[3] 张泽敏, 黄仕艺, 于兰芳, 等.人工肝血浆置换联合胆红素吸附治疗对重症肝炎患者炎症因子的影响[J].中华医院感染学杂志, 2014, 24 (8):1830-1832.
[4] 张洪宪, 赵磊, 侯小飞, 等.血浆置换治疗肾移植术后抗体介导的急性排斥反应的疗效观察[J].中华泌尿外科杂志, 2015, 36 (1):20-23.
[5] 毕颖异, 王海峰, 李欣, 等.双重血浆分子吸附术治疗高胆红素血症的应用及护理[J].中日友好医院学报, 2015, 29 (1):37-38.
[6] 司瑞芬, 张国顺, 王玉兰, 等.低置换量血浆置换联合血浆吸附治疗慢性重型肝炎的临床研究[J].中国煤炭工业医学杂志, 2009, 12 (8):1206-1208.
[7] 张爱民, 游绍莉, 万志红, 等.血浆吸附灌流联合血浆置换加用恩替卡韦治疗乙型肝炎相关慢加急性肝衰竭的临床疗效[J].临床肝胆病杂志, 2012, 28 (10):744-746.
[8] 魏屏, 李红, 李慧, 等.胱抑素C在肝衰竭患者血清中的表达及血浆置换治疗前后的变化[J].华中科技大学学报 (医学版), 2013, 42 (4):473-475.
[9] 唐学兰.前列腺素E1联合血浆置换治疗慢性重型肝炎的临床研究[J].中国医药, 2011, 6 (4):411-412.
[10] 宋树芬, 陈美珠.血浆置换联合HB-H-6树脂血浆吸附治疗慢性肝炎重度黄疸临床观察[J].生物医学工程与临床, 2010, 14 (3):212-214.
[11] 金珍婧, 田月丽, 李东复, 等.慢性肝病患者外周血Ghrelin与炎性细胞因子的水平检测及其相关性研究[J].中国免疫学杂志, 2009, 25 (12):1129-1132.
[12] 郭会敏, 李颖, 朱彦涛, 等.36例人工肝胆红素吸附治疗肝衰竭病人的护理[J].护理研究, 2015, (19):2423-2424.
-
计量
- 文章访问数: 352
- PDF下载数: 208
- 施引文献: 0
下载: