黄芪建中汤加味联合西乐葆对太阴虚寒型胃癌前病变的组织学和IL-10/IL-17A等影响

施伟国; 应华娜; 郭淦华

doi:10.3969/j.issn.1671-038X.2017.11.04

黄芪建中汤加味联合西乐葆对太阴虚寒型胃癌前病变的组织学和IL-10/IL-17A等影响

- 1. 慈溪市第三人民医院消化内科, 浙江慈溪 315324;
- 2. 余姚市中医医院内科, 浙江余姚 315400
基金项目:
2015年慈溪市科技计划科研项目(No:CN2015027)

详细信息

作者简介:
施伟国,男,本科,主治医师,研究方向:中西医结合消化内科

通讯作者: 郭淦华,E-mail:guoganhua1@163.com

中图分类号: R735

收稿日期: 2017-07-10

Effects of Huang qi Jian zhong Tang combined with Celebrex on precancerous lesion histology and IL-10/IL-17 A in patients with deficiency cold of the spleen

- 1. Department of Gastroenterology, Cixi Third People's Hospital, Cixi 315324, China;
- 2. Department of Internal Medicine, Yuyao Traditional Chinese Medicine Hospital, Yuyao 315400, China

More Information

Corresponding author: GUO Gan-hua, E-mail: guoganhua1@163.com

Received Date: 10 July 2017

摘要

摘要: [目的]观察黄芪建中汤加味联合西乐葆对太阴虚寒型胃癌前病变患者细胞因子的表达和临床疗效。[方法]选取80例诊断为胃癌前病变且中医辨证为太阴虚寒证的患者,分为观察组、对照组,每组各40例。所以患者均采用对因和对症基础治疗,并予观察组黄芪建中汤加味联合西乐葆治疗,予对照组西乐葆治疗。疗程各8周,观察治疗前后胃镜下组织学变化,外周血IFN-α、IFN-γ、IL-2、IL-4、IL-6、IL10、IL-17A表达水平,血常规改变等。[结果]治疗8周后,与治疗前比较,观察组病理学在肠上皮化生、萎缩、异型增生、炎症方面均部分逆转(P＜0.05),对照组仅在炎症上缓解(P＜0.05);与对照组比较,治疗组外周血IFN-γ、IL10、IL-17A明显升高,差异有统计学意义(P＜0.05),血红蛋白明显上升,差异有统计学意义(P＜0.05);Hp转阴率明显高,差异有统计学意义(P＜0.05)。[结论]黄芪建中汤加味联合西乐葆通过上调IFN-γ、IL-10、IL-17A的表达水平,对太阴虚寒型胃癌前病变患者的组织学有改善逆转作用。
- 癌前病变 /
- IL-10 /
- IL-17A /
- 组织学 /
- 中西医结合
Abstract: [Objective]To observe the expression of cytokines and clinical efficacy of Huangqi jianzhong soup and celebrex in patients with castric precancerous lesions of spleen and stomach Deficiency type.[Methods]80 patients,diagnosed as castric precancerous lesions of spleen and stomach Deficiency type,were equally divided into observation group and control group.All patients were treated with underlying and symptomatic treatment.Simultaneously,the observation group was given Huangqi Jianzhong soup and celebre.The control group was treated with Celebrex.One course of treatment was 8 weeks.Histological changes,the level of IFN-α,IFN-γ,IL-2,IL-4,IL-6,IL-10 and IL-17 A expression in peripheral blood of patients and the changes of blood parameters before and after the treatment were observed.[Results]After 8 weeks treatment,we found that the pathology in intestinal metaplasia,atrophy,dysplasia,inflammation were partially reversed in observation group(P<0.05).However,in the control group,only inflammation was reversed(P<0.05).Furthermore,we found that the levels of IFN-γ,IL-10 and IL-17 A in the peripheral blood of the treatment group were significantly higher than those of the control group(P<0.05),at the same time,the hemoglobin and Hp negative rate were significantly higher than the control group(P＜0.05).[Conclusion]Huangqi jianzhong soup combined with Celebrex can improve and reverse the histology of patients deficiency cold of the spleen,by raising the IFN-α,IL-10,IL-17 A gamma.
- precancerous lesion /
- IL-10 /
- IL-17A /
- histology /
- integrated traditional Chinese and Western Medicine

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