NGAL通路关键因子与溃疡性结肠炎复发的相关性研究及临床应用

刘海燕; 陈军贤; 徐平珍; 谢齐贵

doi:10.3969/j.issn.1671-038X.2017.11.03

NGAL通路关键因子与溃疡性结肠炎复发的相关性研究及临床应用

- 浙江省立同德医院消化内科, 浙江杭州 310012
基金项目:
公益技术研究社会发展项目(No:2014C33208)

详细信息

作者简介:
刘海燕,女,硕士,副主任医师,研究方向:炎症性肠胃病,消化道癌前病变及早癌的诊治

通讯作者: 刘海燕,E-mail:13725501@qq.com

中图分类号: R574.62

收稿日期: 2017-07-20

Correlation between the key factor of NGAL pathway and recurrence of ulcerative colitis and its clinical application

- Department of Gastroenterology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, China

More Information

Corresponding author: LIU Hai-yan, E-mail: 13725501@qq.com

Received Date: 20 July 2017

摘要

摘要: [目的]探究NGAL通路关键因子与溃疡性结肠炎复发的相关性研究及临床应用。[方法]随机收集我院收治的89例溃疡性结肠炎患者,根据其严重程度分为轻、中度UC组与重度UC组,分别检测患者体内的NGAL通路关键因子水平,并对比分析两组患者治疗缓解后的复发情况。[结果]治疗前重度UC组患者的血清NGAL水平明显高于轻、中度UC组患者,差异有统计学意义(P＜0.05)。治疗后重度UC组患者的血清NGAL水平与轻、中度UC组患者相比未见明显差异(P＞0.05)。治疗缓解患者重度UC组停药后3个月、停药后6个月的复发率明显高轻、中度UC组患者,差异有统计学意义(P＜0.05)。[结论]NGAL水平在溃疡性结肠炎患者中明显升高,且疾病活动程度越高,其NGAL水平升高越明显,患者的复发率也随之升高,控制患者NGAL水平,有利于预防疾病复发,具有重要临床意义。
- NGAL通路关键因子 /
- 溃疡性结肠炎 /
- 复发 /
- 相关性
Abstract: [Objective]To study the correlation between the key factor of NGAL pathway and the recurrence of ulcerative colitis and its clinical application.[Methods]89 patients with ulcerative colitis were randomly selected.According to the severity of ulcerative colitis,the patients were divided into mild and moderate UC group and severe UC group.The levels of NGAL pathways in the patients were detected,and the relapse rate of the two groups was analyzed retrospectively.[Results]Serum NGAL levels in patients with severe UC were significantly higher than those in patients with mild to moderate UC(P<0.05).The recurrence rate of severe UC group was significantly higher than that of moderate UC group at 3 months and 6 months after remission(P<0.05).[Conclusion]The level of NGAL in patients with ulcerative colitis was significantly increased.And the higher the degree of disease activity,the more obvious NGAL levels increased.At the same time the recurrence rate of patients was also increased,It may have important clinical significance to control the levels of NGAL in patients with UC for prevention of disease recurrence.
- NGAL pathway key factor /
- Ulcerative colitis /
- Relapse /
- Correlation

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